ISSN:
1432-0983
Keywords:
β-isopropylmalate dehydrogenase
;
Allelic variation
;
Genome organisation
;
Candida maltosa
;
Silent genes
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract Three different alleles of the β-isopropylmalate dehydrogenase gene were cloned and sequenced from a leucine auxotrophic mutant, G587, of Candida maltosa. The cloning of functionally-intact wild-type genes from this mutant strain suggests the presence of silent gene copies. An interallelic-divergence comparison has provided evidence for new regulatory mechanisms. Sequence data and karyotype analysis argue for a highly-aneuploid genome of C. maltosa. An interpretation for the spontaneous auxotrophy-prototrophy-auxotrophy sequence of mutations in C. maltosa is suggested.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00309549