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Digitale Medien

Interleukin-1β and interleukin-1α stimulate the N-acetyl-β-glucosaminidase activity of human synovial cells (1987)

Clarris, B. J. ; Fraser, J. R. E. ; Ash, P. ; [weitere]

Springer

Rheumatology international 7 (1987), S. 271-275

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Details

ISSN: 1437-160X

Schlagwort(e): Synovial cells ; N-acetyl-β-glucosaminidase ; Interleukin-1 ; Synovial activator ; Rheumatoid arthritis

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary The properties of synovial cells are altered in vitro by monocyte-macrophage polypeptides (monokines), and these changes could explain some of the properties of the inflamed synovium in rheumatoid disease. Purified monokines have become available only recently for testing on the target synovial cells. We report here that purified human interleukin (IL)-1β and recombinant human Il-1α stimulate the extracellular activity of the lysosomal hydrolase, N-acetyl-β-glucosaminidase (NAG), of human synovial fibroblast-like cells. In contrast, another monokine, synovial activator, does not increase the NAG activity. Thus NAG is another cellular activity which can be modulated by interleukin-1.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00270528

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