ISSN:
1433-0350
Keywords:
Keywords Angiogenesis
;
Glioblastoma multiforme
;
Immunohistochemistry
;
Tenascin-C
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Tenascin-C (TN-C) plays an important part in the growth of neoplastic tissue, leading to new vessel development. TN-C has been assessed in adult glioblastoma multiforme (GBM) and has been evaluated as anti-neoplastic therapy. No studies have focused on this tissue in paediatric GBM. Tissues were obtained from six paediatric supratentorial GBMs. Immunohistochemistry was performed using a mouse antibody directed against human TN-C, and expression in tumour vasculature was described on the basis of TN-C immunoreactivity. The expression was minimal in three, moderate in two, and intense in one specimen. TN-C was not correlated with clinical history, neurological findings, or with tumour site. Although based on a limited number of patients, this study provides additional insights into tumour growth modulation and cytogenetic profile of paediatric GBM. The detailed understanding of events responsible for GBM growth is a prerequisite for the development of therapeutic modalities leading to improved prognosis and cure.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s003810050531
