ISSN:
1432-0533
Keywords:
Creutzfeldt-Jakob disease
;
Slow virus
;
Pathology
;
Ultrastructure
;
Intranuclear vacuolar inclusion
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In a 53-year-old man with a progressive mental deterioration and myoclonic jerks, brain biopsy failed to show any significant light microscopical findings. Electron microscopy revealed membranebound vacuolar inclusions in many neuronal nuclei as the only prominent finding. Hamsters intracerebrally inoculated with the biopsy material demonstrated typical spongiform changes in the gray structures of the brain when sacrificed on the 309th and 332nd days post inoculation, characteristic of experimental Creutzfeldt-Jakob disease (CJD). These intranuclear vacuolar inclusions, originally reported in experimental Creutzfeldt-Jakob disease in this laboratory, may be a valuable electron microscopic feature in some CJD cases and may play an important role in supporting the diagnosis of CJD.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00686980
