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Axonal swellings in the corticospinal tracts in amyotrophic lateral sclerosis (1990)

Okamoto, K. ; Hirai, S. ; Shoji, M. ; [et al.]

Springer

Acta neuropathologica 80 (1990), S. 222-226

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ISSN: 1432-0533

Keywords: Amyotrophic lateral sclerosis ; Spheroid ; Corticospinal tract

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary In 2 of 16 cases with sporadic amyotrophic lateral sclerosis (ALS) large numbers of axonal swellings were observed in the corticospinal tracts over a region extending from the posterior limbs of internal capsules to the bulbar pyramids. On electron microscopy, these axonal swellings were seen to consist of accumulations of neurofilaments and altered neuronal organelles (mitochondria and secondary lysosomes). Their morphology differed from the spheroids seen in the anterior horn in ALS.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00308929

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