ISSN:
1432-0533
Keywords:
KeyWordsIschemia
;
Hypothermia
;
Brain Immature
;
Rat
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract We describe a method of focal cooling of the head and its effects on hypoxic-ischemic cerebral damage in neonatal rat. Focal cooling of the head was obtained by positioning a catheter under the scalp ipsilateral to the ligated common carotid artery and by running cold water through the catheter during 2 h of systemic hypoxia. Hypoxia was produced in neonatal rats by breathing 8 % oxygen for 2 h in a 37 °C chamber. Animals underwent focal cooling with ipsilateral scalp temperatures ranging from 22 °C to 35 °C. Temperature recordings from the ipsilateral scalp, cerebral hemisphere (dorsal hippocampus) and core (rectal) were obtained. The results suggest that the method is effective in cooling of brain and also to a lesser extent in lowering of the core temperature. At a mean scalp temperature of 28 °C, mean hippocampal temperature in hypoxic rat was 29.5 °C and mean core temperature in hypoxic rat was 32.8 °C. At a lower scalp temperature of 22 °C, mean hippocampal temperature in hypoxic rat was 24.7 °C and mean core temperature was 31.3 °C. Neuropathologic examination 3–4 days following hypoxia-ischemia showed that focal cooling with a scalp temperature of lower than 28 °C completely protected from brain damage, and that there was a trend towards greater damage with higher scalp temperatures.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00293321
