ISSN:
1432-041X
Keywords:
Spinal cord explant cultures
;
Innervation
;
Sensory connections
;
Topography of afferent terminals
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary Cultured spinal cord explants in which little spontaneous bioelectric activity was present showed, when monitored using sensory ganglion-evoked monosynaptic action potentials, diffuse innervation by ingrowing afferent fibers at 3–4 weeks in vitro. In contrast, highly active cultures of the same age showed a strong tendency for functional sensory connections to be made within the dorsal half of the cord. Regional specificity was present in mature cultures (4–5 weeks in vitro), however, even when their spontaneous activity level was low. The results support earlier results using tetrodotoxin, and make it appear likely that centrally generated neuronal discharges can influence the topography of afferent terminals within the developing spinal cord.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00375781
