ISSN:
1432-1076
Keywords:
Systemic lupus erythematosus
;
Activated T cells
;
Human leukocyte antigens-DR
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Correlation between T cell phenotypes, especially activated T cells expressing early (EA1) and late (HLA-DR) activation antigens and clinical features were investigated in 22 patients with systemic lupus erythematosus (SLE) of childhood onset. Percentages of T cells expressing EA1 and HLA-DR in 22 patients with SLE were significantly higher than those in controls. Comparison of T cell phenotypes between patients with active and inactive SLE showed that eight patients with active disease had significantly increased percentages of HLA-DR positive T cells than 14 with inactive disease (P〈0.01). Serial examinations showed that the percentages of HLA-DR positive T cells were decreased after therapy in seven with active non-renal or active non-renal and renal diseases but not in one with only active renal disease. A possible significance of T cells expressing EA1 and HLA-DR in the management of patients with SLE is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00441516
