ISSN:
1432-1076
Keywords:
Key words L-asparaginase
;
Acute pancreatitis
;
Trypsin
;
Elastase-1
;
Acute lymphocytic leukaemia
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Although there is abundant literature on the association of L-asparaginase and acute pancreatitis in patients undergoing chemotherapy, few studies have investigated the usefulness of pancreatic enzyme measurement in the early diagnosis of L-asparaginase-induced acute pancreatitis. We measured levels of serum pancreatic enzymes before, during, and after L-asparaginase therapy in nine children with acute lymphocytic leukaemia or non-Hodgkin lymphoma. Serum levels of amylase, pancreatic isoamylase, and lipase did not change between the 1st and 30th day of L-asparaginase administration. However, the serum trypsin and elastase-1 levels, 10 and 20 days after beginning L-asparaginase therapy, were significantly higher than those prior to therapy. Conclusion L-asparaginase may induce subclinical pancreatitis and the estimation of serum trypsin and elastase-1 may be useful in the early diagnosis of L-asparaginase-induced acute pancreatitis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004310050878
