ISSN:
1432-1335
Keywords:
Key words Whole-body hyperthermia
;
Nephrotoxicity
;
Ifosfamide
;
Carboplatin
;
Etoposide
;
AbbreviationsICE ifosfamide, carboplatin, etoposide
;
e-WBH extracorporeal whole-body hyperthemia
;
r-WBH radiant-heat-induced whole-body hyperthermia
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Although whole-body hyperthermia combined with specific genotoxic chemotherapy can be shown to enhance neoplastic cell killing without a concomitant rise in bone marrow toxicity, nephrotoxicity can become treatment-limiting. This study compares the kidney toxicity to the kidney of ifosfamide, carboplatin and etoposide (ICE) chemotherapy alone, and ICE chemotherapy combined with either extracorporeal (e-WBH) or radiant-heat-induced hyperthermia (r-WBH) in 43 patients with refractory sarcoma. Within 3 days of ICE chemotherapy treatment there was a significant increase in urinary protein excretion and a reduction of the glomerular filtration rate. These effects were more pronounced if WBH was added. The use of immunoluminometric assays revealed a predominance of low-molecular-mass proteins. This increase in protein excretion persisted in the e-WBH-treated group, whereas it vanished within 3 weeks in both the group treated with ICE alone and that treated with r-WBH. Our findings suggest that ICE chemotherapy causes transient tubular and glomerular damage, which is enhanced by WBH. In terms of long-term nephrotoxicity e-WBH was more nephrotoxic than r-WBH. This finding is consistent with our clinical observations.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004320050028
