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Digitale Medien

Leptin inhibition of insulin secretion from isolated human islets (1997)

Fehmann, H. C. ; Berghöfer, P. ; Brandhorst, D. ; [weitere]

Springer

Acta diabetologica 34 (1997), S. 249-252

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Details

ISSN: 1432-5233

Schlagwort(e): Key words Leptin ; Insulin secretion ; Endocrine pancreas ; β-cells

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Leptin is a hormone produced and secreted from the adipose tissue. Its physiological actions include the regulation of satiety, food intake and energy balance. The production of leptin is increased by high insulin levels. Here, we demonstrate that leptin acts as an inhibitor of glucose-induced (20 mM) insulin secretion from isolated human islets. No effect was observed in the presence of lower glucose levels (2.8 and 10 mM glucose). The pancreatic β-cell might represent a target of a direct physiological action of leptin. We suggest the presence of an “adipo-insular axis” in which leptin mediates negative feedback from the adipose tissue to the endocrine pancreas.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/s005920050083

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