ISSN:
1432-1432
Keywords:
Heat-shock proteins
;
HSP70
;
Stress-70
;
Phylogenetic trees
;
Protein families
;
NLS
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract The eukaryotic cyto-/nucleoplasmatic 70-kDa heat-shock protein (HSP70) has homologues in the endoplasmic reticulum as well as in bacteria, mitochondria, and plastids. We selected a representative subset from the large number of sequenced stress-70 family members which covers all known branches of the protein family and calculated and manually improved an alignment. Here we present the consensus sequence of the aligned proteins and putative nuclear localization signals (NLS) in the eukaryotic HSP70 homologues. The phylogenetic relationships of the stress-70 group family members were estimated by use of different computation methods. We present a phylogenetic tree containing all known stress-70 subfamilies and demonstrate the usefulness of stress-70 protein sequences for the estimation of intertaxonic phylogeny.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00178252
