ISSN:
0942-0940
Keywords:
Aminoglycosides
;
Gentamicin-resistance
;
Netilmicin
;
pneumococcus
;
staphylococcus aureus and epidermidis
;
ventriculitis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In ventriculitis caused by Gentamicin-resistant staphylococcus aureus and staphylococcus epidermidis, Netilmicin was administered intrathecally to 19 patients under continuous control of the Netilmicin concentration in cerebro-spinal fluid (CSF). This therapy was able to bring these otherwise letal infections under control, usually within 10 days. Pharmacokinetic studies with different doses have shown that doses of 2 × 3 mg are to be recommended in moderately severe cases of ventriculitis, and in most severe infections 3 × 3 mg daily intraventricularly for adults. In infants daily intraventricular injections of 2 × 0,4–0,5mg Netilmicin are a sufficient dose to produce an effective antibiotic concentration level.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01402289
