ISSN:
1435-1463
Keywords:
Tranylcypromine enantiomers
;
monoamine uptake
;
monoamine release
;
dopamine
;
noradrenaline
;
serotonin
;
synaptosome
;
imipramine binding
;
blood platelet
;
stereoselectivity
;
rat
;
rabbit
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Studies were carried outin vitro to determine effects of tranylcypromine enantiomers ([+]- and [−]-TCP) on uptake and release of 5-HT, DA and NA in rat synaptosomes and on imipramine binding to rabbit platelets. (+)-TCP was more potent than (−)-TCP as inhibitor of 5-HT uptake and imipramine binding, whereas (−)-TCP was more potent than (+)-TCP as inhibitor of DA and NA uptake. The enantiomers differed only slightly in their effects on monoamine release. The findings agree with previous reports on the stereoselectivity of monoaminergic mechanisms toward TCP enantiomers, and support the notion that the 5-HT uptake site may be associated with the imipramine binding site.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01256489
