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Studies on interferon induction by Newcastle disease virus (NDV) (1969)

Kohno, S. ; Kohase, M. ; Shimizu, Y.

Springer

Archives of virology 28 (1969), S. 188-196

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ISSN: 1432-8798

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Heat- and acid-treatments of EG-NDV, which was essentially a very poor inducer of interferon in PCE cells, resulted in the development of the potency to stimulate interferon synthesis. Optimum temperature to bring about the activation was 56° C, and the peak of the potency was obtained after 4–6 minutes. Effective pH range was 1.6–2.5. Neutral and alkaline pH did not exhibit the stimulatory effect. A hypothetical mechanism to interprete the observed facts is presented, which assumes a heat- and acid-labile component in the virion inhibitory to the induction or synthesis of interferon in PCE cells.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01249383

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