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Binding of polyriboinosinic-polyribocytidylic acid with cultured cells (1975)

Kohno, S. ; Shirasawa, N. ; Umino, Yukiko ; [et al.]

Springer

Archives of virology 49 (1975), S. 229-237

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ISSN: 1432-8798

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Homogenates prepared from polyriboinosinic-polyribocytidylic acid copolymer [poly(rI) · poly(rC)]-treated cells exhibited antiviral activity in chick embryo, L and rabbit kidney cells. The antiviral activity in the homogenate co-sedimented with cellular membrane material and was shown to be poly(rI)·poly(rC) by a hybridization competition test with immobilized polyribocytidylic acid. The results indicate that poly(rI)·poly(rC) binds firmly to cellular membrane. These studies, however, could not differentiate between specific binding leading to the interferon induction and non-specific binding possibly unrelated to the induction of interferon.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01317541

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