ISSN:
1438-2199
Keywords:
Keywords: Amino acids
;
Spinal cord injury
;
Heme oxygenase
;
Heat shock protein
;
Carbon monoxide
;
Growth factors
;
BDNF
;
IGF-1
;
Immunohistochemistry
;
Cell injury
;
Spinal cord edema
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary. The influence of brain derived neurotrophic factor (BDNF) or insulin like growth factor-1 (IGF-1) on spinal cord trauma induced carbon monoxide (CO) production and cellular stress response was examined using immunostaining of the constitutive isoform of the hemeoxygenase (HO-2) enzyme and the heat shock protein (HSP 72 kD) expression in a rat model. Subjection of rats to a 5 h spinal trauma inflicted by an incision into the right dorsal horn at T10–11 segment markedly upregulated the HO-2 and HSP expression in the adjacent spinal cord segments (T9 and T12). Pretreatment with BDNF or IGF-1 significantly attenuated the trauma induced HSP expression. The upregulation of HO-2 was also considerably reduced. These results show that BDNF and IGF-1 attenuate cellular stress response and production of CO following spinal cord injury which seems to be the key factors in neurotrophins induced neuroprotection.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s007260070066
