ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
The aim of this study is to reveal the response of highly malignant tumor cell to differenthydroxyapatite particles. Human’s highly malignant melanoma (MM) cell line A875 is exposed totwo kinds of short-rod hydroxyapatite particles. After incubated with hydroxyapatite particles atdifferent time points, the effects of MM cell morphology, proliferation and invasion are evaluatedby SEM, MTT, and MMP2 protein immunohistochemistry respectively. SEM figures show thatsuperficial sentus of MM cells reduce; more secretion is found; and smaller HA particles have moreobvious effect. At the same time, no statistic difference can be found in MTT assay and MMP2expression measurement. This study also provides useful information about biosecurity ofhydroxyapatite ceramic in transplantation after highly malignant tumor excision
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/52/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.279.pdf
