ISSN:
1662-9779
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Physics
Notes:
Solid lipid nanoparticles(SLN) appear a promising approach as a drug system for topicalapplication. The solid lipid matrices allow protection of incorporated active ingredients againstchemical and physical degradation. This paper deals with controllable preparation of solid lipidnanoparticles based on the phase behaviors of hot microemulsions. The pseudoternary phasediagram for the system of glyceryl monostearate(GMS)/ mixed surfactants (polyoxyethylene(40)stearate(S-40) and poloxamer 188 (F-68))/ water was obtained at 60 ℃ using self-made apparatuswith temperature control. The mass ratios of glyceryl monostearate(GMS), mixed surfactants andwater were determined according to the region of w/o hot microemulsion. It was shown that the sizeof TP-SLN increased slightly with the increasing of concentration of TP, polydispersity index wasapproximately 0.5, encapsulation efficiency decreased distinctly. The percutaneous absorptionexperiment of tea polyphenols loaded SLN through the rabbit skin were conducted using self-madeFranz diffusion cell in vitro. The transdermal penetration was sustained
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/02/23/transtech_doi~10.4028%252Fwww.scientific.net%252FSSP.121-123.705.pdf
