Electronic Resource
s.l. ; Stafa-Zurich, Switzerland
Solid state phenomena
Vol. 121-123 (Mar. 2007), p. 847-850
ISSN:
1662-9779
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Physics
Notes:
The solid lipid nanoparticles (SLNs) were prepared based on the phase behaviors of hotmicroemulsions which were quite different from normal microemulisons for the solid lipid as oilphase. The pseudoternary phase diagrams for the system Brij78/deoxycholic acid sodium (DAS)/glycerol monostearate (GMS)/water with and without the addition of retinoic acid (RA) wereobtained at 60[removed info] using home-made apparatus with temperature control. O/W and W/O region were allfound in the phase diagram. The introduction of RA has increased the O/W microemulsion regiongreatly. GMS-SLN and RA-GMS-SLN were prepared by direct cooling of hot O/W microemulsionobtained according to the phase behaviors results. The mean particle size of GMS-SLN andRA-GMS-SLN investigated by PCS is about 10 nm. TEM images indicated that both SLNs werespherical particles with diameter about 10 nm. PCS results showed that the particle dimension waskept almost the same after three months, proving good stability of both SLNs. The study on the phasebehaviors of drug-loading hot microemulsions has been proved to be very significative for thecontrollable preparation of SLNs which could be used as nanoscale drug delivery system (DDS) forwater insoluble drugs
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/02/23/transtech_doi~10.4028%252Fwww.scientific.net%252FSSP.121-123.847.pdf
| Library |
Location |
Call Number |
Volume/Issue/Year |
Availability |
