ISSN:
1600-0560
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
The cytoskeletal intermediate filaments of pigmented nevi and malignant melanomas (nine cases of each) were evaluated using monospecific antibodies against intermediate filament proteins and immunofluorescence microscopy. Both pigmented nevi and cutaneous malignant melanomas showed only vimentin-type intermediate filaments, hut not keratin, neurofilaments, desmin or glial fibrillary acidic protein. Thus, nevi and melanomas do not show neural characteristics in the cytoskeletal intermediate filament pattern although they appear lo show other neural markers. Vimentin – content in melanomas versus keratin – content in carcinomas may he used as a differential diagnostic feature.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1600-0560.1983.tb00325.x