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Beta-endorphin levels are reduced in peripheral blood mononuclear cells of cluster headache patients (1993)

Leone, M ; Sacerdote, P ; D'Amico, D ; [et al.]

USA/Oxford, UK : Blackwell Science Ltd

Cephalalgia 13 (1993), S. 0

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ISSN: 1468-2982

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Opioid system hypofunction has been postulated in cluster headache (CH) on the basis of reduced opioid levels found in the cerebrospinal fluid (CSF). In this study beta-endorphin levels were monitored in the peripheral blood mononuclear cells of 65 episodic CH patients (32 in remission and 33 in cluster period) and 50 healthy controls. Beta-endorphin levels were significantly lower than controls in CH patients experiencing both phases of the illness (ANOVA, p 〈 0.0001). The persistence of this abnormality during pain-free remission suggests a primary alteration in the regulation of beta-endorphin in peripheral blood mononuclear cells. We speculate that these findings reflect reduced CNS levels of beta-endorphin in CH.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1046/j.1468-2982.1993.1306413.x

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