ISSN:
1440-1681
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
1. The role of putative neurotransmitters was investigated in morphine-induced Straub reaction (SR) in albino mice.2. Apomorphine (15 mg/kg) was also effective in inducing SR. However, in a smaller dose (0.2 mg/kg) it blocked SR induced by morphine.3. Morphine-induced SR was potentiated by tranylcypromine, reserpine (acute effect), imipramine and l-dopa and blocked by reserpine (chronic effect), α-methyldopa, pimozide, chlorpromazine, haloperidol and metoclopramide. Prazosin and clonidine partially blocked morphine SR in high doses.4. Propranolol, yohimbine, cyproheptadine and atropine were ineffective in blocking morphine SR.5. The results indicate that morphine SR is mediated through release of DA in the CNS which excites central D2 receptors. Activation of central α1-adrenoceptors might also play a minor role.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1440-1681.1988.tb01012.x
