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Digitale Medien

Immunochemical characterization of the abnormal paraprotein in a case of scleromyxoedema (1984)

AYALA, F. ; BALATO, N. ; CEPARANO, S. ; [weitere]

Oxford, UK : Blackwell Publishing Ltd

Clinical and experimental dermatology 9 (1984), S. 0

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Details

ISSN: 1365-2230

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: The monoclonal paraprotein from the serum of a patient with scleromyxoedema was characterized as IgG-λ. class. No abnormalities involving antigenic properties of the Fab, Fc, and Fd portions of the molecule were observed.In order to examine the paraprotein thoroughly, IgG was isolated from the scrum by a standard procedure that unexpectedly induced an inexplicable cleavage of the molecule and evidenced an unusual hidden Fc deficiency of monoclonal protein. The hypothesis about significant structural abnormalities of this scleromyxoedema paraprotein was supported by its sedimentation coefficient (S20,w= 6.41) and molecular weight (104,000 daltons).

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1365-2230.1984.tb00815.x

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