Digitale Medien
Oxford, UK
:
Blackwell Publishing Ltd
Clinical and experimental dermatology
18 (1993), S. 0
ISSN:
1365-2230
Quelle:
Blackwell Publishing Journal Backfiles 1879-2005
Thema:
Medizin
Notizen:
Matrigel is a solubilized tissue basement membrane gel extracted from the mouse Engelbreth–Holm–Swarm sarcoma. Cultures of human endothelia! cells could be induced to undergo extremely rapid morphological differentiation into capillary-like structures by Matrigel. The present study demonstrates the following: (a) Matrigel-induced tube formation by endothelial cells is laminin-dependent and, particularly, the YIGSR peptide site in the B1 chain of laminin may be necessary for endothelial cell differentiation resulting in capillary formation; (b) endothelial cells may be preprogrammed for rapid differentiation into blood vessels and do not require DNA, RNA or protein synthesis in order to undergo tube formation on Matrigel; and (c) microfilament assembly and function is important for Matrigel-induced tube formation.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1111/j.1365-2230.1993.tb02177.x
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