Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
British journal of dermatology
88 (1973), S. 0
ISSN:
1365-2133
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
A case of scleromyxoedema (lichen myxoedematosus) associated with an IgG1, type kappa paraproteinaemia is reported.Culture of bone marrow material demonstrated that this tissue synthesized monoclonal IgG (subclass γ I) with a light chain of type kappa. The culture of a biopsy specimen of the diseased skin demonstrated low-speed IgG synthesis. It is concluded that the bone marrow and pathological skin synthesize a paraprotein with the same characteristics as that in the serum.Microchemical analysis of pathological skin demonstrated an increase in the content of neutral glycoproteins, hyaluronic acid and chondroitin sulphates as well as the presence of heparin and keratan sulphates.It could not be demonstrated that the serum of this patient contained antibody against connective tissue ground substance or other skin constituents.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-2133.1973.tb07515.x
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