ISSN:
1471-4159
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
The monoaminergic fibres enter the hippocampal formation through a dorsal and a ventral route. The dorsal route consisting of fimbria, fornix superior and cingulum, was estimated to supply about 75% of the 5-HT fibres and 40% of the noradrenaline containing (NA) fibres. The ventral route, allegedly passing through the amygdaloid area, accounts for the rest. The cingulum bundle contributes a definite part of the 5-HT fibres but very few of the NA fibres. No evidence was found for an intrinsic origin of monoaminergic fibres in the hippocampal region. Monoamine oxidase and catechol-O-methyltransferase showed no change following the lesions and are considered to be localized predominantly outside the aminergic neurones. The results on DOPA decarboxylase indicate that about 50% of the enzyme is situated outside 5-HT and NA nerves. Glutamic acid decarboxylase did not decrease even after transection of the ventral route, substantiating the earlier conclusion that this enzyme is situated in intrinsic neurones in the hippocampal region. For choline acetyltransferase and AChE the dorsal route was confirmed to be the only quantitatively important way of access. None of the enzymes studied, nor the uptake activities, were affected by cervical sympathectomy.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1471-4159.1974.tb04297.x
