ISSN:
1365-3083
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
In studying 150 cases of gastric cancer, 93 (62%) were found to be CEA-positive. Among them, 5 cases had concurrent elevation of serum AFP over 200 ng/ml and appearance of serum CPALP. Further, there were another 2 cases simultaneously positive in serum CPALP. All these 7 cases were of pathologically well-differentiated adenocarcinoma with liver metastases.Immunohistologically, CEA was observed on the surface of cancer cells as well as in glandular lumens of cancer tissues, forming a centroglandular pattern, while CPALP was detected in cytoplasm of cancer cells generally but absent in glandular lumens, and no formation of centroglandular pattern was observed. In contrast, most of the cancer cells were found AFP-negative except for some cancer cells with abundant chromatin in nucleus and acidophilic cytoplasm, in which AFP was detected in cytoplasm. Furthermore, AFP was also scarcely observed in cytoplasm of some normal liver transient cells scattered close to metastatic cancer lesions, suggesting that in gastric cancer, occurrences of CEA, AFP and CPALP originate from cancer cells while mild amounts of AFP are also being synthesized in some normal liver transient cells scattered close to metastatic cancer lesions.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-3083.1978.tb03964.x
