Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Scandinavian journal of immunology
7 (1978), S. 0
ISSN:
1365-3083
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Pretreatment with d-Penicillamine of rat peritoneal macrophages markedly influences their ability to modulate Concanavalin A stimulated [3H]thymidine incorporation in non-adherent rat lymph node cells. Untreated macrophages added in high numbers to the lymphocytes (ratio lymphocytes/macrophage 7.5:1) depress their [3H]thymidine incorporation. Pretreatment with d-Penicillamine further reduces this response. Lower proportions of untreated macrophages (ratio 15:1) exert a stimulatory effect on the lymphocytes. This response is reversed by pretreatment of macrophages with d-Penicillamine. Addition of untreated macrophages in very low proportions (40:1 and 75:1) is without effect on the [3H]thymidine incorporation by the lymphocytes. This response is markedly stimulated by pretreatment of the macrophages with d-Penicillamine. The culture of macrophages in the presence of D-Penicillamine increases their incorporation of [3H]d-glucosamine, but it is without effect on their incorporation of [3H]l-leucine. It is suggested that d-Penicillamine enhances the functional activity of the macrophage in the regulation of the lymphocyte response to mitogens.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-3083.1978.tb00453.x
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