Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Scandinavian journal of immunology
6 (1977), S. 0
ISSN:
1365-3083
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
This study showed that under well-defined conditions all immunoglobulins could be removed from the rat mast cell surface. Surface immunoglobulins were examined by immunofluorescence technique, and cell function by the allergic reaction to antigen as judged by histamine release. Refixation of eluted surface Ig to the mast cell was easily accomplished. Furthermore, fixation of specific surface Ig to already sensitized cells resulted in inreased cell sensitivity to antigen, whereas fixation of nonspecific surface Ig resulted in decreased sensitivity. The results indicate that removed immunoglobulins are intact, have affinity for mast cells, and are able to compete with cell-bound Ig.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-3083.1977.tb00337.x
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