Digitale Medien
Oxford, UK
:
Blackwell Publishing Ltd
Scandinavian journal of immunology
1 (1972), S. 0
ISSN:
1365-3083
Quelle:
Blackwell Publishing Journal Backfiles 1879-2005
Thema:
Medizin
Notizen:
Ninety macroglobulinaemia sera were tested for occurrence of multiple mono clonal immunoglobulins. Thirteen (14%) of the sera contained more than one monoclonal immunoglobulin. The homogeneous macroglobulins were isolated from 3 sera; in each case individually specific antigenic determinants common to the two components were demonstrated, in addition to determinants unique for each component. NH2-terminal amino acid sequence studies in two pa tients showed that the IgM heterogeneity was due to differences in the primary structure of the variable parts of the x (case To) and the μ (case Nae) chains. Macroglobulinaemia appears to be a unique source of homogeneous immuno-globulins from related clones.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1111/j.1365-3083.1972.00019.pp.x
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