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Randomised, double-blind, placebo controlled pilot study assessing nitroglycerin as a tocolytic (1999)

Smith, Graeme N. ; Walker, Mark C. ; McGrath, Michael J.

Oxford, UK : Blackwell Publishing Ltd

BJOG 106 (1999), S. 0

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ISSN: 1471-0528

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Thirty-three women in preterm labour were randomised in a double-blind fashion to receive either transdermal nitroglycerin (n= 17) or placebo (n= 16). Both groups had significant (P 〈 0.001) change in the cervix prior to randomisation. The primary outcome measure was delivery within 48 hours of randomisation. Fewer women randomised to nitroglycerin treatment (6/17) were delivered within 48 hours, compared with the placebo treatment (10/16) (RR 0.56, 95% CI 0–27 to 1.19). This pilot study lends support to two case series published that suggest that transdermal nitroglycerin may be promising as a safe, effective means for tocolysis.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1471-0528.1999.tb08376.x

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