ISSN:
1542-474X
Quelle:
Blackwell Publishing Journal Backfiles 1879-2005
Thema:
Medizin
Notizen:
Background: The prolongation of P-wave duration has long been shown to indicate the presence of high risk for atrial fibrillation. The circadian variation of P-wave characteristics and their dynamic adaptation to heart rate changes was not tested before.Methods: To evaluate the diurnal pattern of P-wave duration, P area, and PR interval and of their linearly fitted relation with RR interval, 50 healthy volunteers (25 men, mean age 34 ± 10 years) underwent 24-hour ambulatory electrocardiographic (ECG) recording with digital 12-lead Holter recorders. The median P-wave duration, P area, and PR interval were calculated from the average 12-lead ECG constructed from each 10-second ECC recording. Single harmonic regression analysis was performed to reveal the presence of circadian variation in the aforementioned ECG parameters.Results: The P area (P 〈 0.0001, R2= 0.78), the PR interval (P 〈 0.0001, R2= 0.92), the P area / RR slope (P 〈 0.0001, R2= 0.55), and the PR/RR slope (P 〈 0.0001, R2= 0.42) showed a highly significant circadian variation while the periodic nature of P-wave duration (P = 0.016, R2= 0.32) and of the P duration / RR slope (P = 0.011, R2= 0.18) was only indicated by harmonic regression analysis.Conclusions: P-wave duration, P area, and PR interval show a significant circadian variation in healthy subjects. The relations between P area/RR,PR/ RR, and P duration/RR also demonstrate a significant diurnal pattern. A.N.E. 2001;6(2):92–97
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1111/j.1542-474X.2001.tb00092.x
