Electronic Resource
Oxford BSL
:
Blackwell Science Ltd
Clinical & experimental allergy
30 (2000), S. 0
ISSN:
1365-2222
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Several studies suggest that endogenous glucocorticoids can dampen the severity of experimental allergic reactions in animals.〈section xml:id="abs1-2"〉〈title type="main"〉ObjectiveTo investigate the influence that endogenous glucocorticoids have on the course of IgE-mediated pulmonary early and late phase reactions.〈section xml:id="abs1-3"〉〈title type="main"〉MethodsTwenty-one allergic asthmatic and six healthy control subjects underwent inhaled antigen challenge with measurements of plasma cortisol and cortisone by gas chromatography-mass spectrometry.〈section xml:id="abs1-4"〉〈title type="main"〉ResultsThere were no differences between the asthmatic and control groups in the baseline levels of cortisol or cortisone. However, the asthmatic subjects had significantly higher cortisol levels (67.2 ± 8.6 vs 35.1 ± 4.5 ng/mL; P = 0.04) and had higher cortisol/cortisone ratios (4.8 ± 0.6 vs 3.0 ± 0.2; P = 0.01) 8 h after challenge compared to the control subjects. Among the asthmatic subjects, those whose FEV1 recovered rapidly had higher baseline levels of cortisol and those who displayed a late phase reaction had lower levels of cortisol during the late phase period.〈section xml:id="abs1-5"〉〈title type="main"〉ConclusionThe results suggest that endogenous glucocorticoids may play a significant role in the modulation of airway responses to antigen challenge, and that antigen challenge may induce cortisol production in allergic subjects.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1046/j.1365-2222.2000.00890.x
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