ISSN:
1365-4632
Quelle:
Blackwell Publishing Journal Backfiles 1879-2005
Thema:
Medizin
Notizen:
A 45-year-old male cook was seen for the evaluation and removal of a “mole on my eye” of steady growth during the previous 6 months. The patient stated that he had had a “brown spot” above his left eye for 17 years prior to its recent enlargement; it was now partly blocking the vision in his left eye. He denied a history or family history of cutaneous tumors, including skin cancer. On examination, a 2.5-cm × 0.5-cm × 0.8-cm, horn-like, darkly pigmented, cutaneous nodule was evident extending from the left upper eyelid downwards to below the lower eyelid (〈link href="#f1 #f2"〉Figs 1 and 2). He also had scattered, skin-colored, 2–3-mm cystic papules on his anterior mid-chest. A shave excision specimen was obtained from the eyelid nodule.〈figure xml:id="f1"〉1〈mediaResource alt="image" href="urn:x-wiley:00119059:IJD1848:IJD_1848_f1"/〉Horn-like, cutaneous nodule extending from the left upper eyelid downwards to below the lower eyelid〈figure xml:id="f2"〉2〈mediaResource alt="image" href="urn:x-wiley:00119059:IJD1848:IJD_1848_f2"/〉Close up, demonstrating the morphologic features to better advantageMicroscopic examination demonstrated acanthosis, hyperkeratosis, and papillomatosis (〈link href="#f3"〉Fig. 3). Large dendritic cells with abundant melanin granules were spread throughout the epidermis. In addition, small basaloid or spinous keratinocytes were present in the malpighian layer.〈figure xml:id="f3"〉3〈mediaResource alt="image" href="urn:x-wiley:00119059:IJD1848:IJD_1848_f3"/〉Histology of the nodule, showing an epidermis with acanthosis, hyperkeratosis, papillomatosis, and large dendritic cells with abundant melanin granules spread throughout the epidermis (hematoxylin and eosin; original magnification, × 100)
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1111/j.1365-4632.2004.01848.x
