ISSN:
1600-079X
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Trávníčková Z, Illnerová H. Melatonin entrainment of the circadian N-acetyltransferase rhythm in the newborn rat pineal gland. J. Pineal Res. 1997; 23:136–141. © Munksgaard, Copenhagen〈section xml:id="abs1-1"〉〈title type="main"〉AbstractIn 15-day-old control and vehicle-treated rats, the evening rise of the pineal N-acetyltransferase occurred at the same time as in their mothers, whereas in 5-day-old pups, the rise occurred by 2–3 hr earlier. Four-day administration of melatonin in the late day phase advanced the N-acetyltransferase rise in 15-day-old rats as compared with the rise in the vehicle-treated animals; a slight melatonin induced phase advance in 5- and 27-day-old rats was not significant. The data indicate that the newborn rat's circadian pacemaker controlling the rhythmic N-acetyltransferase rise may be entrained by exogenous melatonin. It appears, however, that the maternal melatonin transferred via milk cannot entrain the pup's pacemaker by phase advancing it, since the N-acetyltransferase rise in the pups begins earlier or at the same time as maternal melatonin production driven by the N-acetyltransferase rhythm.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1600-079X.1997.tb00346.x
