ISSN:
1600-0714
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Background: Although considerable insight has been gamed into Epstein–Barr virus (EBV) as an important etiologic factor in various tumors, virtually little is known about the relationship between EBV genes and oral tumors.Method: Thirty-two cases of nonodontogenic tumor (16 squamous cell carcinomas, 11 salivary gland tumors, 1 malignant lymphoma, 1 spindle cell sarcoma, 1 osteogenic sarcoma, 1 malignant fibrous histiocytoma and 1 verrucous carcinoma), 17 cases of odontogenic tumor (17 ameloblastomas, the most important and common type of odontogenic tumor) and 12 cases of normal oral tissue (8 normal gingival tissues and other oral mucosa) were examined for the presence of EBV-DNA, with primers specific for the BamW, BNRF1, BMLF1, BamC, IR3, BMRF1, EBNA-2A BamhY, and EBNA-2B BamhY region of the EBV genome by the polymerase chain reaction (PCR).Results: Fifty-three percent (17/32) of nonodontogenic tumors, forty-eight percent (8/17) of ameloblastomas, and ninety-two percent (11/12) of normal oral tissues were positive for EBV-DNA. Of the EBV-DNA, BMLF1 demonstrated the strongest reactivity in the nonodontogenic tumors, and BamC demonstrated the strongest reactivity in the ameloblastomas and normal oral mucosae.Conclusions: Taken into account with the expression of different EBV genes in odontogenic and nonodontogenic tumors, these findings suggest that even though odontgenic tumors and nonodontogenic tumors are relatively unique, the appearance of different EBV genes seems to suggest the complicated roles that the EBV genes play.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1034/j.1600-0714.2001.301005.x
