Digitale Medien
Oxford, UK
:
Blackwell Publishing Ltd
Journal of the European Academy of Dermatology and Venereology
13 (1999), S. 0
ISSN:
1468-3083
Quelle:
Blackwell Publishing Journal Backfiles 1879-2005
Thema:
Medizin
Notizen:
Vitiligo is a common disease of unknown cause that produces disfiguring white patches of depigmentation. Previous studies have suggested the effectiveness of UV-B radiation in generalized vitiligo (GV) therapy, but there was no evidence to support the same role for segmental vitiligo (SV).〈section xml:id="abs1-3"〉〈title type="main"〉ObjectiveThe purpose of this study was to use UV-B radiation exclusively on vitiligo patches of individuals affected by S V to evaluate the effectiveness of this therapy.〈section xml:id="abs1-4"〉〈title type="main"〉Subjects and methodsEight individuals with SV were treated for 6 months with a new device called BIOSKIN® that can produce a focused beam of UV-B (microphoto-therapy) on vitiligo patches only. Photographs of the subjects were taken at the beginning of the therapy and once a month thereafter for 6 months. The response to treatment was estimated in two comparable photographs using planimetry. A control group of eight individuals matched for sex and age was treated with placebo, using the same device but not releasing any kind of detectable light.〈section xml:id="abs1-5"〉〈title type="main"〉ResultsAfter 6 months of microphototherapy five subjects of the eight studied achieved normal pigmentation on more than 75% of the treated areas. In particular, three of these were totally repigmented. Two individuals achieved 50–75% pigmentation of the treated areas, and only one showed less than 50% repigmentation (Table 3). In the control group only one patient showed moderate repigmentation (less than 50%) (Table 3) (Fig. 3).〈section xml:id="abs1-6"〉〈title type="main"〉ConclusionUV-B microphototherapy seems highly effective in restoring pigmentation in patients affected by vitiligo. As no side-effects have been observed, this could represent the treatment of choice in the limited (segmental) forms of vitiligo.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1111/j.1468-3083.1999.tb00861.x
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