Electronic Resource
Munksgaard
:
Munksgaard International Publishers
Journal of clinical periodontology
26 (1999), S. 0
ISSN:
1600-051X
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Abstract. The host immune response in chronic marginal periodontitis (CMP) raised against bacteria colonizing the dentogingival area is modulated by cytokines. This study examines the distribution of the transforming growth factor-β1 containing (TGF-β1 +) cells in formalin-fixed and paraffinembedded gingival specimens from 11 patients with chronic marginal periodontitis and 7 persons with healthy gingiva. Inflamed periodontal tissue contained a 100-fold more TGF-β1 + cells than healthy gingiva. Diverse morphological TGF-β1 + cell types were discerned. Double immuno-enzymatic and -fluorescence staining revealed that TGFβ1 + cells comprised 21–29% macrophages 2–3% T-cells, 3–9% B-cells, 34–35% neutrophilic granulocytes and 7–10% mast cells. The densities of all TGF-β1 + cell types in CMP were strongly increased in the connective tissue adjacent to the pocket epithelium, in the lamina propria and adjacent to the oral epithelium. In lesions with extensive inflammation, expression was also marked in pocket epithelium. TGF-β1 is an immunosuppressive cytokine that stimulates wound healing. Upregulation of the cytokine in inflamed gingiva may counterbalance for destructive gingival inflammatory responses that are simultaneously taking place in patients with CMP.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1034/j.1600-051X.1999.260606.x
| Library |
Location |
Call Number |
Volume/Issue/Year |
Availability |
