ISSN:
1524-475X
Quelle:
Blackwell Publishing Journal Backfiles 1879-2005
Thema:
Medizin
Notizen:
Aim: Clinical researches using allogeneic CDS, developed in the R & D Center for Artificial Skin of Kitasato University, have been carried out in 30 medical centers across Japan. The clinical results in our hospital, especially focusing on the treatment of refractory ulcers and dermal burns, were reported in this study. Methods: The CDS was prepared by plating cultured fibroblasts on a spongy matrix of hyaluronic acid and atelo-collagen. The CDS was used in 13 clinical trials, including 6 refractory ulcers, 4 dermal burns, 1 skin defect left behind preparing skin flaps, and 2 skin defects left behind removal of scar. The use of CDS in conjunction with a conventional ointment-gauze dressing was repeated at an interval of 4 to 7 days over a period of 2 to 6 weeks. Results: The successful application with CDS was achieved in all cases. Especially, in case of refractory ulcers, failed to heal even by using trafermin (Fiblast spray®) or other ointments, a complete healing was achieved in one case and wound size reduction was observed in other 5 cases within 6 weeks. Conclusions: Our results suggest that the CDS is effective in the treatment of refractory ulcers and other skin defects. The excellent clinical results seem to be related to the cytokines released from the CDS.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1111/j.1067-1927.2004.abstractas.x
