Digitale Medien
Oxford, UK; Malden, USA
:
Blackwell Publishing Ltd/Inc.
Scandinavian journal of immunology
62 (2005), S. 0
ISSN:
1365-3083
Quelle:
Blackwell Publishing Journal Backfiles 1879-2005
Thema:
Medizin
Notizen:
Mouse hepatitis virus 3 (MHV3) infection of A/J and BALB/c mice has been used as a model of resistance/susceptibility. A/J mice recover from a mild disease after 4–6 days of infection and the BALB/c mice develop an acute hepatitis and die after 3–4 days of infection. In view of studying the MHV3 binding to cells or cell extracts, we performed an enzyme-linked immunosorbent assay-like virus-binding assay, preparing microplates with L929 cells, A/J or BALB/c mouse macrophages and also with proteins extracted from these cells. Higher MHV3 bindings were observed to proteins of BALB/c macrophages than to the A/J ones. The interferon-γ (IFN-γ) activation led to a reduction of MHV3 binding only to proteins of resistant A/J mouse macrophages. Our experiments contribute to the hypothesis that IFN-γ activation of macrophages plays an important role against MHV3 infection by downregulating the expression of viral receptors.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1111/j.1365-3083.2005.01616.x
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