ISSN:
1432-8798
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The mechanism of resistance to foot-and-mouth disease virus (FMDV) which occurs 2 days after divinyl ether-maleic only anhydride (pyran copolymer) treatment but diminishes by the 7th day was investigated. Adsorption of virus by minced infant mouse spleen, muscle, kidney, heart or liver was not affected either at 2 days or 7 days after treatment of the mice with pyran. However,in vitro multiplication of FMDV in minced kidney was affected by pyran at both times. The resistance of mice 2 days after treatment was related to absence of virus in muscle, kidney, and spleen tissues. Seven days after pyran administration, however, FMDV was recovered from muscle and spleen but not kidney. Interferon was recovered from various tissues 2 days but not 7 days after mice were injected with pyran. Other unknown polymer-induced antiviral factors as well as interferon may have been related to the resistance mechanism.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01249854
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