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  • Articles: DFG German National Licenses  (12)
  • 1990-1994  (4)
  • 1985-1989  (8)
  • 1990  (4)
  • 1985  (8)
Source
  • Articles: DFG German National Licenses  (12)
Material
Years
  • 1990-1994  (4)
  • 1985-1989  (8)
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    A GREEK GRAFFITO FROM AREZZO (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Oxford journal of archaeology 4 (1985), S. 0 
    Details
    ISSN: 1468-0092
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Archaeology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-0092.1985.tb00236.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Uptake of CO2 by aquatic vegetation (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Plant, cell & environment 8 (1985), S. 0 
    Details
    ISSN: 1365-3040
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract Photosynthesis by aquatic plants based on the supply of CO2 from air-equilibrated solutions may be limited by the low diffusion coefficient of CO2 in water. For plants in which the transport of CO2 from the bulk medium is by diffusion, and the initial carboxylation uses RUBISCO, CO2 supply can be increased by growth in habitats with fast water flow over the surface (reducing unstirred layer thickness), or with heterotrophically-augmented CO2 levels, including the direct use of sediment CO2. Many aquatic plants using RUBISCO as their initial carboxylase counter the limitations on CO2 supply via the operation of biophysical CO2 concentrating mechanisms which are based on active transport of HCO−3, CO2 or H+ at the plasmalemma, and use bulk-phase HCO−3 or CO2 as the C source. A final group of aquatic plants use biochemical CO2 concentrating mechanisms based on auxiliary carboxylation by PEPc: C4-like and Crassulacean Acid Metabolism–like processes are involved. These various mechanisms for increasing CO2 supply to RUBISCO also help to offset the low specific reaction rate of aquatic plant RUBISCOs at low [CO2] and low [CO2]: [CO2]. In addition to overcoming restrictions on CO2 supply, the various methods of increasing inorganic C availability may also be important in alleviating shortages of nitrogen or photons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3040.1985.tb01677.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Regulatory functions of the three nodD genes of Rhizobium leguminosarum biovar phaseoli (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Molecular microbiology 4 (1990), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The three nodD genes of a strain of Rhizobium leguminosarum biovar phaseoli were cloned to study their effects on transcription of themselves and of the nodC genes of biovars phaseoli and viciae. Efficient transcription of nodD1 required nodD1 and was enhanced by exposure of the cells to bean exudate consistent with the presence of a nod-box preceding the nolE-nodD1 operon. Transcription of nodD2 and nodDZ was constitutive. nodC of R. leguminosarum biovar phaseoli was activated by each of the nodD genes of that biovar in the absence of inducers but expression was enhanced in cells grown with bean exudate or the flavonoids genistein or naringenin. A mutant of nodD2, tacking 60bp at its 3’end, activated nodC in the presence of inducer, but was defective in regulating certain of the nodD genes. The nodC gene of R. leguminosarum biovar viciae responded differently to the various nodD genes of R. leguminosarum biovar phaseoli than did the nodC of the latter biovar.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.1990.tb00666.x
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  • 4
    Electronic Resource
    Electronic Resource
    Analysis of three nodD genes in Rhizobium leguminosarum biovar phaseoli; nodD 1 is preceded by nolE, a gene whose product is secreted from the cytoplasm (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Molecular microbiology 4 (1990), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: In a strain of Rhizobium leguminosarum biovar phaseoli, three copies of the regulatory nodulation gene nodD were identified on the Sym plasmid and sequenced. Two were closely linked to each other and the third was near, but not adjacent, to the nodABC genes. Each of these nodD genes could correct the Nod defect of a nodD mutant strain of R. leguminosarum biovar viciae on peas. A truncated form of nodD2 could also correct this mutant, indicating that the C-terminus of NodD2 is not needed for inducing activity. Upstream of nodD1 and in the same operon is a newly described gene, nolE, whose product appears to be exported into the periplasm. Close to nodD2 is another gene, nolP, with no known counterpart in other rhizobia. Both nolP and nolE-nodD1 are preceded by ‘nod-box’ sequences and, in the former case, there appear to be two tandemly repeated nod-box sequences. Mutations in each of the nodD genes and in the nolE and nolP genes did not abolish nodulation or nitrogen fixation on beans.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.1990.tb00665.x
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    The relationship between clearance of theophylline and age within the adult age range (1985)
    Springer
    European journal of clinical pharmacology 29 (1985), S. 177-179 
    Details
    ISSN: 1432-1041
    Keywords: theophylline clearance ; age ; adult age range ; normal subjects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Twenty volunteers aged between 20 and 57 years were given 197 mg of theophylline (as lysine theophylline) by iv infusion over 5 minutes to test the hypothesis that within the adult age range theophylline clearance declines with age. Samples were assayed for theophylline using the EMIT assay and clearance was determined by standard methods. Clearance values were 0.73 ml/min/kg below age 38 years and 0.75 ml/min/kg at and above age 38 years. Multiple regression analysis using age as a continuous variable showed no relationship between age and clearance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00547418
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    The acute changes in serum binding of disopyramide and flecainide after myocardial infarction (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 253-255 
    Details
    ISSN: 1432-1041
    Keywords: disopyramide ; flecainide ; myocardial infarction ; drug plasma binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In the serum basic drugs are principally bound to alpha1-acid glycoprotein (AAG). Following acute myocardial infarction it has been shown that the levels of AAG rise. The serum levels of total protein, albumin, AAG and the protein binding of 2 antiarrhythmic drugs which are bases, disopyramide and flecainide, was measured in vitro with blood samples from eleven patients taken over the first 5 days following myocardial infarction. Mean AAG levels significantly increased from 1.04 g/l on Day 1 to 1.80 g/l on Day 5. The binding of disopyramide, which is highly bound, rose from 80% to 87%, representing a 35% decrease in free drug concentration. In contrast the binding of flecainide fell from 61% to 53%, a 20% increase in free drug concentration. These data suggest that although the binding of strongly bound drugs responds appropriately to increases in binding protein after acute myocardial infarction, poorly bound drugs are displaced from binding sites possibly by endogenous substances. Since the pharmacological effects of a drug are related to its free (unbound) concentration, the changes in the proportions of free to bound drug after myocardial infarction may have important clinical implications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543319
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    An examination of a possible pharmacokinetic interaction between nifedipine and antipyrine (1990)
    Springer
    European journal of clinical pharmacology 39 (1990), S. 405-407 
    Details
    ISSN: 1432-1041
    Keywords: Nifedipine ; antipyrine ; interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The influence of 2 weeks oral intake of nifedipine (2×20 mg) on the oxidative metabolism of antipyrine was investigated in 12 normal volunteers, who had 1050 mg antipyrine solution orally before and after the course of nifedipine. There were no statistically significant differences in the saliva pharmacokinetic parameters of antipyrine on both occasions. However, the metabolite profile of antipyrine in urine showed a significant reduction in the amount of norantipyrine excreted after compared to that before nifedipine administration (16.5 vs 19.6%). This may have implications for drugs that share a similar demethylation pathway with norantipyrine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315420
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Medifoxamine: Oral tolerance and pharmacokinetic study in healthy human volunteers (1990)
    Springer
    European journal of clinical pharmacology 39 (1990), S. 169-171 
    Details
    ISSN: 1432-1041
    Keywords: antidepressant ; medifoxamine ; tolerance ; pharmacokinetics healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Medifoxamine is a monoamine reuptake inhibiting antidepressant drug. We have investigated its pharmacokinetics in normal healthy volunteers. After an overnight fast, ascending doses of 200, 500, 750 and 1000 mg of medifoxamine were taken orally. Plasma samples were analysed using a specific HPLC method. Medifoxamine was well tolerated and exhibited a first order linear pharmacokinetic profile. It underwent rapid absorption and peak plasma concentrations were achieved about 1.0 h after administration. Thereafter the elimination profile was biphasic with a mean terminal half life less than 3 hours. We found a linear relationship (r=0.80) between administered dose and AUC values for the four doses. High values were obtained for the apparent volumes of distribution and the plasma clearance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00280053
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    psi, a plasmid-linked Rhizobium phaseoli gene that inhibits exopolysaccharide production and which is required for symbiotic nitrogen fixation (1985)
    Springer
    Molecular genetics and genomics 200 (1985), S. 278-282 
    Details
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A strain of R. phaseoli cured of its symbiotic plasmid, pRP2JI, retained the ability to make exopolysaccharide (EPS). However, a region of pRP2JI, when cloned at an increased copy number in wide host-range vectors and transferred to this and other strains of Rhizobium, inhibited EPS synthesis. The gene responsible was termed psi (polysaccharide inhibition) and was located in a region of the symbiotic plasmid close to nodulation and nitrogen fixation genes. psi is important in the symbiosis since a wild-type strain containing psi cloned on a multicopy plasmid failed to form Phaseolus nodules, and mutant strains containing psi::Tn5 mutations failed to fix nitrogen in Phaseolus nodules. It is proposed that the function of psi may be to repress in the bacteriod the expression of genes such as those for EPS synthesis which are normally expressed in free-living culture.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00425436
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Identification of the host-range DNA which allows Rhizobium leguminosarum strain TOM to nodulate cv. Afghanistan peas (1985)
    Springer
    Molecular genetics and genomics 201 (1985), S. 296-300 
    Details
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The special ability of Rhizobium leguminosarum strain TOM to nodulate cv. Afghanistan peas had previously been shown to be determined by the symbiotic plasmid, pRL5JI, of this strain. A region of pRL5JI, 2.0 kb in size, was found to confer the ability to nodulate cv. Afghanistan peas when transferred to strains of R. leguminosarum which normally fail to nodulate this host. This region of pRL5JI, responsible for the extension of host-range, was closely linked to, but did not include, the genes required for root hair curling. Although extensive homology has been found between the R. leguminosarum nod genes on pRL5JI and those on the normal symbiotic plasmid pRL1JI, a fragment from the 2.0 kb region involved in nodulation of cv. Afghanistan has been identified, which was not homologous to DNA in strains which do not nodulate cv. Afghanistan.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00425674
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    Paper (German National Licenses)
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