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  • Articles: DFG German National Licenses  (3)
  • 1990-1994  (3)
  • 1980-1984
  • 1991  (3)
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  • Articles: DFG German National Licenses  (3)
Material
Years
  • 1990-1994  (3)
  • 1980-1984
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Inhibition of potassium outward currents and pacemaker current in sheep cardiac Purkinje fibres by the verapamil derivative YS 035 (1991)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 344 (1991), S. 653-661 
    Details
    ISSN: 1432-1912
    Keywords: Sheep Purkinje fibre ; Action potential ; Potassium outward currents ; Pacemaker current ; YS 035
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The electrophysiologic mode of action and potency of the verapamil derivative YS 035 (N,N-bis-(3,4-dimethoxyphenethyl)-N-methyl amine) were investigated in sheep cardiac Purkinje fibres. Action potential duration measured at a repolarization level of −60 mV (APD-60) and membrane currents recorded with the two-microelectrode voltage-clamp technique were evaluated. At 10 μmol/l YS 035 APD-60 was increased to about 115% of reference. Prolongation measured as percentage of the respective control exhibited on the average no dependence on stimulation frequency (0.17–2 Hz). At 100 μmol/l membrane became depolarized to about −50 mV and action potentials could no longer be elicited. Further study was focussed on effects on outward currents, mostly activated at a frequency of 0.05 Hz. Transient outward current (ito) was completely blocked at 100 μmol/l and half-maximal inhibition occurred at about 14 μmol/l. Inwardly rectifying potassium current (iK1) was reduced to 47% of reference at 100 μmol/l. An initially activating outward current at positive membrane potentials (iinst) was reduced to 73% at 100 μmol/l. Time-dependent (delayed) outward current (iK) was on the average not affected up to 100 μol/l. Besides inhibition of repolarizing outward currents YS 035 completely blocked pacemaker current (if) at 100 μmol/l and half-maximal reduction was achieved at 5 μmol/l. YS 035 (1–100 μmol/l) did not clearly affect time constants of activation at selected test potentials (IK: +35 mV; if: −90 mV) or inactivation (ito: 0 mV). Voltage-dependent control mechanisms of currents (itto, if) were not influenced by YS 035 but the amount of available current was reduced. In conclusion, the verapamil derivative YS 035 inhibited pacemaker current and potassium outward currents which correlated to a prolongation of cardiac action po tentials. Electrophysiological actions of the compound favour it to be tested in vivo as an antiarrhythmic drug candidate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00174749
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    facet.materialart.
    Unknown
    Freedom, Rights and Pornography (1991)
    Woodstock, Md., etc : Periodicals Archive Online (PAO)
    Theological Studies. 52:4 (1991:Dec.) 775 
    Details
    ISSN: 0040-5639
    Topics: Theology and Religious Studies
    Notes: SHORTER NOTICES
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:3258-1991-052-04-000054
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Upper limit for thermal direct photon production in heavy-ion collisions at 60 and 200A·GeV (1991)
    Springer
    The European physical journal 51 (1991), S. 1-10 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The production of direct photons has been investigated in reactions ofp and16O projectiles at 60 and 200A·GeV with C and Au nuclei. Photon and π0 spectra have been measured in the pseudorapidity range 1.5≦η≦2.1 for the transverse momentum region 0.4 GeV/c≦p T ≦2.8 GeV/c employing the lead-glass spectrometer SAPHIR. An upper limit of 15% at the 90% confidence level for the direct photon signal relative to the neutral pion production is obtained from the comparison of measured photon spectra with Monte Carlo simulations of the hadronic background based on the reconstructed yield of π0 and η mesons. Consequences for a possible phase transition to a quark-gluon plasma are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01579555
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    Paper (German National Licenses)
    Fulltext
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