ISSN:
1468-2494
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Intercellular lipids of the stratum corneum contribute threefold to the maintenance of a healthy skin: by hydration, cell adhesion, and reduction of transepidermal water loss. All of these functions can be attributed to the self-organizing property of the amphiphilic molecules of the stratum corneum lipids. A new type of skin care product called Lamellar Gel was developed, which contains a (synthesized) pseudo-ceramide. Its structure is similar to that of ceramide found among the stratum corneum lipids, which allows it to control intramolecular interactions. Compared to regular emulsions the Lamellar Gel demonstrated better skin care characteristics regarding permeability, skin hydration, and skin occlusion. This was attributed to the fact that it formed the same self-organizing structure as natural stratum corneum lipids, hence showing a high affinity to the skin. A high moisturizing effect was observed as the Lamellar Gel combines the benefits of both O/W and W/O emulsions: it provides the same initial hydration as an O/W emulsion and at the same time the same occlusivity as a W/O emulsion. Transepidermal water loss increases under dry environmental conditions. This especially affects the skin around the eyes, where the skin is very thin, and wrinkles are very easily formed. Treatment with the Lamellar Gel recovered these wrinkles promptly and hydrated the stratum corneum for a long time.〈section xml:id="abs1-1"〉〈title type="main"〉ResumeLes lipides intercellulaires de l'epiderme contribuent trois fois au maintien de la sante de la peau: par l'hydratation, l'adhesion cellulaire, et la reduction de la perte d'eau transepidermique. Toutes ces functions peuvent etre attribuees la propriete d'auto-organisation des molecules amphiphiles des lipides de l'epiderme.On a developpe un nouveau type de produit de soin pour la peau, appele le Gel Lamellaire, qui contient un pseudo-ceramide (synthetique). Sa structure est similaire celle du ceramide present dans les lipides de l'epiderme, ce qui lui permet de controler les interactions intramoleculaires.Par rapport aux emulsions classiques le Gel Lamellaire a montre de meilleures proprietes de soin pour la peau vis--vis de la permeabilite, l'hydratation et le recouvrement de la peau. Ceci est attribue au fait qu'il forme la meme structure auto-organisante que les lipides de l'epiderme naturel, presentant pa la une forte affinite avec la peau. Un effet fortement hydratant a ete observe puisque le Gel Lamellaire associe les avantages des emulsions H/E et E/H: il apporte la meme hydratation initiale qu'une emulsion H/E et en meme temps le meme recouvrement qu'une emulsion E/H.La perte d'eau transepidermique augmente en conditions d'atmosphere seche. Ceci touche particulierement la peau du contour de l'oeil, ou la peau est tres fine, et des rides se forment facilement. Un traitement avec le Gel Lamellaire a rapidement resorbe ces rides et hydrate l'epiderme pour une longue duree © Rapid Science Ltd. 1998
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1046/j.1467-2494.1998.171741.x
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