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  • Articles: DFG German National Licenses  (9)
  • 2005-2009  (1)
  • 1995-1999  (4)
  • 1965-1969  (4)
  • 1
    Electronic Resource
    Electronic Resource
    Effect of inhaled corticosteroid on an immunoreactive thymus and activation-regulated chemokine expression in the bronchial biopsies from asthmatics (2005)
    Oxford, UK : Munksgaard International Publishers
    Allergy 60 (2005), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  Bronchial asthma is characterized by airway inflammation, notably because of eosinophils and T cells. Thymus and activation-regulated chemokine (TARC) is known to selectively attract Th2 cells, and is increased in response to interleukin (IL)-4 and IL-13, which share a common receptor, IL-4 receptor alpha (IL-4Rα). While corticosteroids have proven, very effective in modifying airway inflammation, the effect of corticosteroids on TARC in asthmatics has been little studied.Objective:  We examined the effects of inhaled budesonide (BUD) on the expression of TARC and the number of inflammatory cells in bronchial biopsy specimens taken from asthma patients.Methods:  Inhaled BUD 800 μg daily, or placebo was administered for 3 months in a double-blind, parallel-group study, and bronchial biopsies were performed before and after treatment. Biopsy specimens were examined by immunocytochemistry.Results:  We observed a significant decrease in the epithelial expression of TARC (P 〈 0.01) in the BUD group compared with the placebo group. This was accompanied by decreases in the number of eosinophils (P 〈 0.01), CD3+ T cells (P 〈 0.05), and CD4+ T cells (P 〈 0.01). A significant correlation was found between changes in epithelial TARC and in IL-4Rα immunoreactivity (rs = 0.66, P 〈 0.01).Conclusions:  These findings suggest that corticosteroid asthma treatment can reduce infiltration of the airway by inflammatory cells, an effect modulated by down-regulation of bronchial epithelial TARC expression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.2005.00694.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Aminophlline is effective on acute exacerbations of asthma in adults–objective improvements in peak flow, spirogram, arterial blood gas measurements and lung sounds (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 26 (1996), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1996.tb01141.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Timing of the occurrence of frost cracks in winter (1996)
    Springer
    Trees 11 (1996), S. 47-53 
    Details
    ISSN: 0931-1890
    Keywords: Key words Frost crack ; Low temperature ; Freezing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract  In order to determine the timing of the occurrence of frost cracks, as well as to evaluate the climatic conditions associated with such occurrences, study plots were established in late autumn and early winter. Serial observations were made to identify both the occurrence of new frost cracks and the re-opening of old frost cracks in trees in the study plots until mid-winter or early spring. Field observations were conducted for three winter seasons in different study plots. Most old frost cracks were found to re-open in early winter. However, such re-opening did not occur simultaneously within a very limited period of time, for example, within a single day or night, when air temperature fell suddenly or considerably. Re-opening seemed to occur steadily over the course of several days of continuous subzero temperatures. It has been suggested that freezing of the trunk contributes considerably to the re-opening of old frost cracks. Four frost cracks from 1002 trees were newly formed during the course of this study. The new frost cracks developed both in early winter and mid-winter. It has been suggested that new frost cracks can occur during the same period when most old frost cracks re-open and the air temperature does not fall far below 0°C. However, it remains unclear whether or not there is a tendency for new frost cracks to occur during a particular period.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004680050057
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Dissection of a major QTL for photoperiod sensitivity in rice: its association with a gene expressed in an age-dependent manner (1998)
    Springer
    Theoretical and applied genetics 97 (1998), S. 714-720 
    Details
    ISSN: 1432-2242
    Keywords: Key words Oryza sativa L. ; Photoperiod-sensitivity genes ; Quantitative traits ; Gene complex ; Wild rice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  A proposed major quantitative trait locus (QTL) for photoperiod sensitivity on chromosome 6 in rice was examined by introducing a chromosomal segment from a sensitive line into an insensitive one. The crossing experiments showed that a range of variation in heading date occurred in the later generations and that the region might contain at least a major gene and two additional recessive genes controlling photoperiod sensitivity. Gene mapping experiments showed that the major gene was Se-1 and that a recessive gene (tentatively named se-pat) was loosely linked to it. The responses to photoperiods were examined among the different genotypes under natural and controlled conditions. The two genes acted additively on the degree of photoperiod sensitivity. However, se-pat plants showed a response to photoperiods that differed from that of the other sensitive lines; a short-day treatment at the seedling stage delayed heading in the former plants, suggesting that the manner of its expression was age-dependent. A recessive gene similar to se-pat seemed to be widely distributed in wild and cultivated rice, suggesting that the gene complex in the region plays a significant role in response to photoperiod.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001220050947
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Freezing behavior of xylem ray parenchyma cells in softwood species with differences in the organization of cell walls (1999)
    Springer
    Protoplasma 206 (1999), S. 31-40 
    Details
    ISSN: 1615-6102
    Keywords: Freezing tolerance ; Xylem ray parenchyma cells ; Cell wall ultrastructure ; Supercooling ; Cryo-scanning electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary By cryo-scanning electron microscopy we examined the effects of the organization of the cell walls of xylem ray parenchyma cells on freezing behavior, namely, the capacity for supercooling and extracellular freezing, in various softwood species. Distinct differences in organization of the cell wall were associated with differences in freezing behavior. Xylem ray parenchyma cells with thin, unlignified primary walls in the entire region (all cells inSciadopitys verticillata and immature cells inPinus densiflora) or in most of the region (mature cells inP. densiflora and all cells inP. pariflora var.pentaphylla) responded to freezing conditions by extracellular freezing, whereas xylem ray parenchyma cells with thick, lignified primary walls (all cells inCrytomeria japonica) or secondary walls (all cells inLarix leptolepis) in most regions responded to freezing by supercooling. The freezing behavior of xylem ray parenchyma cells inL. leptolepis changed seasonally from supercooling in summer to extracellular freezing in winter, even though no detectable changes in the organization of cell walls were apparent. These results in the examined softwood species indicate that freezing behavior of xylem ray parenchyma cells changes in parallel not only with clear differences in the organization of cell walls but also with subtle sub-electron-microscopic differences, probably, in the structure of the cell wall.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01279251
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Fluorescence microscopic observations of catecholamines in cultures of the sympathetic chains (1967)
    Springer
    Cell & tissue research 80 (1967), S. 345-352 
    Details
    ISSN: 1432-0878
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A histochemical technique for the demonstration of catecholamines developed by Falck et al. has been successfully applied to the sympathetic chains of rats and mice maintained in vitro. Catecholamines were localized in the nerve fibers, showing identical green fluorescence as in tissue sections of healthy rats. The cultures 8 days in vitro exhibited positive reaction in a few terminals, whereas sister cultures 1 month in vitro showed strong fluorescence reaction in thicker proximal axons and networks of nerve fibers as well. Reactivity of neuron somas became positive after 1 month of cultivation. Application of reserpine in amount of 0.00025 mg/ml for 2 hours resulted in complete disappearance of fluorescence. Furthermore, cultures of spinal ganglia from fetal rat produced no fluorescence reaction with this technique. Therefore, the reaction is specific for sympathetic nervous tissue and reliable for the differentiation of sympathetic neurons from other types of nerve cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00339327
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  • 7
    Electronic Resource
    Electronic Resource
    Elektronenmikroskopische Untersuchungen an der Epiphysis cerebri beim Hund (1966)
    Springer
    Cell & tissue research 69 (1966), S. 129-139 
    Details
    ISSN: 1432-0878
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung 1. Die Epiphysis cerebri von 30 Hunden wurde elektronenmikroskopisch im Hinblick auf ihre sekretorische Funktion untersucht. 2. Die Pinealzellen sind sekretorisch tätige Zellen. Das Sekret wird in Form von „synaptischen“ Bläschen im Bereich des Golgi-Apparates produziert. Außer den Bläschen wurden osmiophile Granula (Pigmentgranula und Fetttröpfchen) verschiedener Menge beobachtet. 3. Die Pinealzellen sind multipolare Zellen mit Fortsätzen von verschiedener Länge und Dicke. Sie enden mit keulenförmigen Anschwellungen in den perivaskulären Spalten. 4. Die im Fortsatz enthaltenen Bläschen (Durchmesser 350–1400 Å) besitzen in der Regel ein elektronendichtes Granulum. Sie werden wahrscheinlich durch die Basalmembran in das Kapillarlumen abgegeben. Damit stellt sich der Sekretionsmodus der Zirbeldrüse als ähnlich heraus mit dem bei der Neurosekretion oder bei Abgabe von neurohumoralen Transmitters in der Nervenendigung.
    Notes: Summary The epiphysis of 30 dogs was studied electronmicroscopically. The pineal cells are secretory elements; their product arises from small vesicles in the Golgi apparatus. In addition to such vesicles, osmiophilic granules (pigments and lipids) were observed in varying amounts. The pineal cells are multipolar with processes of diverse length and thickness. These end with bulbous swellings in perivascular clefts. The vesicles found in the processes (diameters 350–1,400 Å) as a rule contain an electron dense granule. They are probably released into the capillary lumen via the basement membrane. Thus the secretory process in the pineal seems to resemble that in neurosecretory centers or that of the site of production of neurohumoral transmitters at nerve endings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00406271
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Weitere elektronenmikroskopische Untersuchungen am kaudalen neurosekretorischen System von Fischen (1966)
    Springer
    Cell & tissue research 75 (1966), S. 328-338 
    Details
    ISSN: 1432-0878
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Das kaudale neurosekretorische System von Cyprinus carpio und Channa argus Cantor wurde elektronenmikroskopisch untersucht. Während in den Golgi-Bläschen von Channa nur eine Art von Elementargranula entsteht, kommen bei Cyprinus zwei Granulatypen verschiedener Größe und Elektronendichte (α- und ß-Granula) vor, jedoch nie in ein und derselben neurosekretorischen Zelle zusammen. Bei Cyprinus werden Elementargranula verschiedener Elektronendichte aus der Zelle in die perivaskulären Räume abgegeben. Außer Elementargranula wurden große Tropfen mit verschiedener Struktur in den Perikaryen und in den Basen der Zell-Fortsätze beobachtet. Ein Teil der Tropfen ist durch Verschmelzung der Elementargranula entstanden, die meisten jedoch entsprechen Lysosomen, Myelinfiguren, „multivesicular bodies“ usw. Die neurosekretorischen Zellen sind durch zahlreiche axo-somatische und axo-axonale sowie axo-dendritische Synapsen mit nichtsekretorischen Nervenzellen verbunden. — Da die Wandungen der endozellulären Kapillaren ohne Zwischenschaltung einer gliösen Schranke die Zellmembran der Perikaryen berühren, wird ein unmittelbarer Stoffaustausch zwischen neurosekretorischen Zellen und Blut vermutet.
    Notes: Summary The caudal neurosecretory system of Cyprinus carpio and Channa argus Cantor was studied electron microscopically. In the secretory nerve cells of both species the elementary granules are formed in the Golgi complex. In the neurosecretory system of Cyprinus carpio two kinds of neurosecretory cells can be differentiated according to the size and the electron density of their granules (α- and ß-granule). Grnules of both types cannot be found in the same neurosecretory cell. In Cyprinus the elementary granules of various density are released into the pericapillary space. Apart from the elementary granules droplets with various structures in the perikarya and bases of the processes were recognized. A part of these droplets consists of accumulated elementary granules, the majority however belongs to inclusions like lysosomes, “myelinfigures”, “multivesicular bodies” and so on. The neurosecretory elements are connected with non-secreting nerve cells by numerous axo-somatic, axo-axonic and axo-dendritic synapses. In Channa argus the perikarya of neurosecretory cells are in close contact with the basement membrane of the capillary, i.e. there is no glial barrier between the neurosecretory cell and the blood vessel.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00407164
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  • 9
    Electronic Resource
    Electronic Resource
    Fluorescence and electron microscopic evidence for the dual innervation of the iris sphincter muscle of the rabbit (1968)
    Springer
    Cell & tissue research 91 (1968), S. 90-95 
    Details
    ISSN: 1432-0878
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The sphincter zone of the rabbit iris sometimes contains terminals with small granular vesicles. These terminals correspond to yellowish-green fluorescent structures in the sphincter zone. The paired arrangement of a terminal containing these vesicles and one full of agranular vesicles might indicate dual innervation of sphincter muscles by sympathetic and parasympathetic fibers. The sympathetic component probably exerts an inhibitory action on the sphincter muscles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00336986
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    Paper (German National Licenses)
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