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  • Articles: DFG German National Licenses  (5)
  • 2000-2004  (3)
  • 1990-1994  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Clinical and immunological effects of low-dose IFN-α treatment in patients with corticosteroid-resistant asthma (2003)
    Oxford, UK : Munksgaard International Publishers
    Allergy 58 (2003), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  Interferon (IFN)-α is a cytokine that possesses potent anti-viral and immunoregulatory activities. We aimed to assess clinical and immunological effects of low-dose IFN-α in patients with severe corticosteroid-resistant asthma with and without Churg–Strauss syndrome. There is currently no efficient pharmacological treatment available for this group of patients.Methods:  We studied 10 patients with corticosteroid-resistant asthma, in which 3×106 IU/day IFN-α were administrated in addition to the prednisone dose given already before introduction of the cytokine therapy. The prednisone dose was gradually reduced dependent on the clinical situation and used as a clinical readout to evaluate the efficacy of the cytokine therapy. To distinguish between IFN-α- and prednisone-mediated immunological changes, the corticosteroid dose was kept constant for at least 2 weeks upon introduction of the cytokine therapy in seven patients. The effects of treatment on clinical and immunological parameters were measured at 2–4 weeks and 5–10 months depending on the availability of the patient.Results:  Interferon-α treatment rapidly improved the clinical situation as assessed by lung function parameters and required prednisone dose. Important immunological changes included: decreased leukocyte numbers, increased relative numbers of CD4+ T cells, increased differentiation of T helper (Th)1 cells, and increased expression of interleukin (IL)-10 in peripheral blood mononuclear cells.Conclusion:  Interferon-α treatment was associated with dramatic improvements in the condition of patients with corticosteroid-resistant asthma with and without Churg–Strauss syndrome. Potential mechanisms of action include the establishment of a correct Th1/Th2 balance and the induction of the anti-inflammatory IL-10 gene.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1398-9995.2003.00424.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Plasmacytoma of the tonsil with AL amyloidosis: evidence of post-fibrillogenic proteolysis of the fibril protein (2000)
    Springer
    Virchows Archiv 436 (2000), S. 336-344 
    Details
    ISSN: 1432-2307
    Keywords: Key words Amyloid ; λ Light chain ; Osseous metaplasia ; Plasmacytoma ; Protease ; Tonsil
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We report of a 58-year-old Caucasian man who was referred to the University Hospital with a greatly enlarged left tonsil which showed calcifications on computed-tomography scans. Histopathology revealed a plasmacytoma with secondary AL amyloidosis, ossifications, and multinucleated foreign-body-type giant cells. N-terminal sequencing of amyloid-fibril proteins purified from the formalin-fixed tissue showed the presence of two proteins of different size; these were of λ-light-chain origin (subgroup V), measured approximately 15.2 kDa and 10.5 kDa, and had identical N-terminal ends (YVLTQPP). When the amyloid deposits were immunolabeled with a polyclonal antibody directed against λ light chain, they showed two staining patterns: some deposits showed intense immunolabeling while others were not immunoreactive. Immunostaining of amyloid was completely absent after protease pre-treatment. Immunoelectron microscopy with gold-labeled secondary antibodies showed staining that was spatially related to amyloid fibrils and suggested that the antibody probably detected the fibril protein. Therefore, our hypothesis in this case is that the different immunostaining patterns are due to a post-fibrillogenic proteolysis of the fibril protein at the C-terminal end of the light chain, as indicated by the presence of two differently sized λ-light-chain fragments with identical N-terminal ends.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050456
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Photofission of235U and238U at intermediate energies: absolute cross sections and fragment mass distributions (1994)
    Springer
    The European physical journal 350 (1994), S. 249-261 
    Details
    ISSN: 1434-601X
    Keywords: 25.20.Dc ; 25.85.Jg ; 27.90.+b
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The total photofission cross section σγ,F for235U and238U has been measured in the energy range 50≤E γ≤800 MeV at the 855 MeV Mainz Microtron MAMI using energy and time tagged photons (Glasgow Tagger) and a 4π arrangement of position sensitive fragment detectors. Besides the absolute photofission cross section σγF , which almost completely exhausts the total photon absorption cross section for these nuclei, fragment mass distributions in this energy domain were determined via time of flight techniques (TOF). The results for the total photofission cross sections σγ,F normalized to the atomic numberA for both isotopes coincide, and agree in theΔ-resonance region, within the systematic errors, with the socalled“Universal Curve” σγ,T /A of the total photon absorption cross section σγ,T . At higher energies the cross sections exhibit a smooth behaviour. In particular, it is shown for the first time that there isno resonance-like shape near the D13 resonance (at ≈710 MeV) as observed for the free proton. This complete suppression of the D13 resonance in complex nuclei is not yet understood on a microscopic level. The fragment mass distributions show a predominantly mass symmetric fission. However, contributions from mass asymmetric fission at some photon energies may give a hint of an increased mass asymmetric fission after the onset of the pion and two pion channels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01289589
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Control of plant growth by nitrogen and phosphorus in mesotrophic fens (1991)
    Springer
    Biogeochemistry 12 (1991), S. 135-148 
    Details
    ISSN: 1573-515X
    Keywords: fens ; management ; nitrogen ; phosphorus ; productivity ; vegetation ; wetlands
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Geosciences
    Notes: Abstract A fertilization experiment was carried out in 3 mesotrophic fens to investigate whether plant growth in these systems is controlled by the availability of N, P or K. The fens are located in an area with high N inputs from precipitation. They are annually mown in the summer to prevent succession to woodland. Above-ground plant biomass increased significantly upon N fertilization in the two “mid”-succession fens studied. In the “late”-succession fen that had been mown for at least 60 years, however, plant biomass increased significantly upon P fertilization. The mowing regime depletes the P pool in the soil, while it keeps N inputs and outputs in balance. A long-term shift occurs from limitation of plant production by N toward limitation by P. Hence, mowing is a suitable management tool to conserve the mesothrophic character of the fens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00001811
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Exploring ADHD age-of-onset criterion in Brazilian adolescents (2000)
    Springer
    European child & adolescent psychiatry 9 (2000), S. 212-218 
    Details
    ISSN: 1435-165X
    Keywords: Key words Attention deficit hyperactivity disorder – hyperkinetic disorders, inattention – hyperactivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Objective: To explore age-of-onset criterion for the diagnosis of attention–deficit hyperactivity disorder (ADHD) in a school sample of young Brazilian adolescents. Methods: 191 students aged 12 to 14 years were evaluated using DSM-IV ADHD criteria, measures of ADHD symptoms and global impairment. Results: Both adolescents with ADHD (n=30) and adolescents who fulfilled all DSM-IV ADHD criteria, except age of onset of impairment criterion (ADHD w/o age-of-onset, n=27) had significantly higher scores on Attention Problems, Delinquent and Aggressive Behavior scales of the Child Behavior Checklist (CBCL) and lower scores on the Child Global Assessment scale (CGAS) than non-ADHD adolescents (n=134). Adolescents with ADHD and youths with ADHD w/o age-of-onset did not differ significantly in any measure assessed. Conclusion: These results concur with recent literature proposing revision of the age-of-onset criterion for the diagnosis of ADHD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007870070045
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    Paper (German National Licenses)
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