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  • 11
    Electronic Resource
    Electronic Resource
    Low-temperature preparation and characterization of SrBi2Ta2O9 thin films on (100)-oriented LaNiO3 electrodes (2000)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 76 (2000), S. 1758-1760 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: SrBi2Ta2O9 (SBT) ferroelectric thin films were prepared by the metalorganic decomposition technique at annealing temperatures of 600 and 650 °C on Pt/Ti/SiO2/Si substrates coated by (100)-oriented LaNiO3 (LNO) metal oxide thin films, which were fabricated by the sol–gel technique combined with a layer-by-layer annealing method at 600 °C. A (200)-predominant SBT thin film can be formed on LaNiO3(100)/Pt/Ti/SiO2/Si substrate at 600 °C. The effect of the LNO oxide electrode on the dielectric and ferroelectric properties of SBT thin film annealed at 600 °C was studied. Although the remanent polarization of the (200)-predominant SBT thin film is not as large as expected, the film can be uniformly polarized and imaged using an atomic force microscope in the piezoelectric mode. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.126158
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  • 12
    Electronic Resource
    Electronic Resource
    72 W Nd:Y3Al5O12 ceramic laser (2001)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 78 (2001), S. 3586-3588 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A high-power continuous-wave polycrystalline 1% Nd:Y3Al5O12 (Nd:YAG) ceramic rod laser was demonstrated. With 290 W/808 nm laser diode pumping, cw laser output of 72 W was obtained at 1064 nm. The optical-to-optical conversion efficiency is 24.8%. Thermally induced birefringence properties of Nd:YAG ceramic was also investigated. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1378053
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  • 13
    Electronic Resource
    Electronic Resource
    Improved interface properties of p-type 6H–SiC/SiO2 system by NH3 pretreatment (2000)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 76 (2000), S. 372-374 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Effects of preoxidation NH3 treatment on p-type 6H–SiC/SiO2 interface properties were investigated as compared to conventional thermally oxidized devices. It was found that NH3 treatment before oxidation can reduce the SiC/SiO2 interface states and fixed oxide charge. Furthermore, less shift of flatband voltage, and smaller increases of effective oxide charge and interface states during high-field stress were observed for the NH3 pretreated devices. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.126120
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  • 14
    Electronic Resource
    Electronic Resource
    Molecular dissection of the primary sink size and its related traits in rice (2004)
    Oxford, UK : Blackwell Publishing Ltd
    Plant breeding 123 (2004), S. 0 
    Details
    ISSN: 1439-0523
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: The genetic mechanism underlying the relationship between three traits of the primary sink size - spikelet number per panicle (SNP), panicle number per plant (PN), and 1000-grain weight (GWT), and their 10 component traits in rice was dissected in 292 F13 recombinant inbred lines using a complete linkage map. A total of 43 genomic regions on 12 rice chromosomes were found to contain quantitative trait loci (QTLs) affecting the sink size traits, which revealed several important aspects of the genetic basis of sink capacity in rice. First, QTLs for SNP, PN and GWT were largely independent. Secondly, most QTLs affecting SNP and GWT showed close characteristics in both genomic locations and directions of effects to QTLs for their components, suggesting that pleiotropy, rather than linkage, was the primary genetic basis of the correlated panicle and grain traits. Thirdly, some QTLs affecting component traits did not contribute to SNP or GWT. In these cases, two or more QTLs with opposite effects on their component traits were detected, which could be due to either linkage or pleiotropy. Fourthly, some QTLs had large effects on panicle number (QPn4), panicle branching and length (QPbn3a, QPbn3b and QPb14), grain length and volume (QG13, QG15 and QGv2), and grain shape (QGs1 and QGs7), which were consistently detected in the related rice mapping populations and in different environments, providing good candidates and useful information for marker-aided improvement of sink size and yield potential of rice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1439-0523.2003.00936.x
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  • 15
    Electronic Resource
    Electronic Resource
    Comparison of Vertical-Flow Constructed Wetlands for the Treatment of Wastewater Containing Lead and Copper (2001)
    Oxford, UK : Blackwell Publishing Ltd
    Water and environment journal 15 (2001), S. 0 
    Details
    ISSN: 1747-6593
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: This paper describes an investigation into the treatment efficiency and capital cost of vertical-flow constructed-wetland filters containing different plant communities and granular media with different adsorption capacities. The media included gravel, sand, granular-activated carbon, charcoal and filtralite (light expanded clay). Lead and copper sulphate were added to a polluted urban beck inflow water to simulate pretreated minewater or highway runoff. The interactions between growth media, microbial and plant composition and the reduction of lead, copper and BOD were investigated. For filters containing traditional media, a breakthrough of copper was recorded during the first nine weeks. After maturation of the biofilm, the wetlands performed well.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1747-6593.2001.tb00356.x
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  • 16
    Electronic Resource
    Electronic Resource
    Gastric medullary carcinoma, a distinct entity associated with microsatellite instability-H, prominent intraepithelial lymphocytes and improved prognosis (2004)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 45 (2004), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aims:  To determine the clinicopathological and molecular features of gastric medullary cancer.Methods and results:  Clinicopathological review and microsatellite instability (MSI) analysis were carried out on 17 gastric medullary and 64 non-medullary cancers. In addition to characteristic histopathology, gastric medullary cancers had certain prominent features: (i) the average survival time was longer in medullary and low-grade non-medullary cancers than in high-grade (P = 0.004); (ii) serosal involvement was less common in medullary cancers (29.4%, 5/17) than in non-medullary cancers (9.4%, 6/64) (P 〈 0.05) while pushing borders were more common in medullary cancers (70.6%, 12/17 versus 17.2%, 11/64, P = 0); (iii) the presence of intraepithelial lymphocytes (IELs) in medullary and non-medullary cancers was 2380/10 high-power field (HPF) and 147/10 HPF (P = 0), respectively. Both peritumoural infiltrating lymphocytes (pTIL) and a Crohn's-like reaction were more common in medullary cancers than in non-medullary (pTIL 35.3%, 6/17 versus 3.1%, 2/64; a Crohn's-like reaction 70.6%, 12/17 versus 32.8%, 21/64; P 〈 0.05); (iv) medullary and high-grade non-medullary cancers were more associated with reduced ECD expression in comparison with low-grade cancers (P 〈 0.05); (v) higher MSI-H (Bat26+) rate was observed in medullary cancers (41.2%, 7/17) than in non-medullary (1.6%, 1/64) (P = 0).Conclusions:  Gastric medullary cancer has distinct clinicopathological features and genetic alterations. Two subtypes of gastric medullary cancers, Bat26+ and Bat26–, might have prognostic implications, thus analysis of Bat26 may be of clinical value.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.2004.01998.x
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  • 17
    Electronic Resource
    Electronic Resource
    Alpha-methylacyl-CoA racemase: a multi-institutional study of a new prostate cancer marker (2004)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 45 (2004), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim : To test whether α-methylacyl-CoA racemase (AMACR) is a sensitive and specific marker of prostate cancer.Methods and results : The expression levels of AMACR mRNA were measured by real-time polymerase chain reaction. A total of 807 prostatic specimens were further examined by immunohistochemistry specific for AMACR. Quantitative immunostaining analyses were carried out by using the ChromaVision Automated Cellular Imaging System and the Ariol SL-50 Imaging System, respectively. AMACR mRNA levels measured in prostatic adenocarcinoma were 55 times higher than those in benign prostate tissue. Of 454 cases of prostatic adenocarcinoma, 441 were positive for AMACR, while 254 of 277 cases of benign prostate were negative for AMACR. The sensitivity and specificity of AMACR immunodetection of prostatic adenocarcinomas were 97% and 92%, respectively. Both positive and negative predictive values were 95%. By automatic imaging analyses, the AMACR immunostaining intensity and percentage in prostatic adenocarcinomas were also significantly higher than those in benign prostatic tissue (105.9 versus 16.1 for intensity, 45.7% versus 0.02% and 35.03% versus 4.64% for percentage, respectively).Conclusions : We have demonstrated the promising features of AMACR as a biomarker for prostate cancer in this large series and the potential to develop automated quantitative diagnostic tests.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.2004.01930.x
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  • 18
    Electronic Resource
    Electronic Resource
    Matrix metalloproteinase-2 from bronchial epithelial cells induces the proliferation of subepithelial fibroblasts (2002)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 32 (2002), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background In bronchial asthma, subepithelial fibrosis in the conducting airways is associated with increased numbers of subepithelial fibroblasts.Objective This study examined the hypothesis that MMP-2 from airway epithelial cells induces the proliferation of subepithelial fibroblasts.Methods Using primary bronchial epithelial cells MMP-2, MT1-MMP and TIMP-2 mRNA expression were assessed by Northern blotting and RT-PCR. Primary bronchial epithelial cells transfected with constructs encoding pro-MMP-2 and MT1-MMP (MMP-14).Results Transfected cells showed enhanced expression of the appropriate mRNA species by RT-PCR and enhanced MMP-2 or MT1-MMP activity by zymography. Active MMP-2 levels in epithelial supernatants were increased most by cotransfection with pro-MMP-2 and MT1-MMP encoding constructs. By measuring tritiated thymidine incorporation, supernatants from transfected cells were found to enhance DNA synthesis of primary airway fibroblast cultures compared with controls. There was a strong correlation (r = 0.9, P 〈 0.01) between MMP-2 levels in epithelial cell conditioned media and fibroblast proliferation as indicated by DNA synthesis. The MMP inhibitor 1,10-phenanthroline attenuated the increased proliferation, while the addition of exogenous purified MMP-2 alone also increased fibroblast proliferation.Conclusions Our results support a role for MMP-2 in mediating cross-talk between epithelial cells and myofibroblasts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2745.2002.01386.x
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  • 19
    Electronic Resource
    Electronic Resource
    Identification and mapping of a rice blast resistance gene Pi-g(t) in the cultivar Guangchangzhan (2004)
    Oxford, UK : Blackwell Science Ltd
    Plant pathology 53 (2004), S. 0 
    Details
    ISSN: 1365-3059
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: A single dominant blast resistance gene was identified in Chinese indica rice (Oryza sativa) cv. Guangchangzhan (GCZ), which shows complete resistance to Japanese isolate Ken53-33 of Magnaporthe grisea. Genetic analysis of the backcross (BC1) and second-generation (F2) populations from a cross between susceptible cv. Lijiangxintuanheigu (LTH) and GCZ indicated that the resistance was conferred by one dominant gene. This gene was mapped on the long arm of chromosome 2 and flanked by RM166 and RM208 at distances of 4·00 ± 4·90 and 6·30 ± 4·89 cM (centiMorgans), respectively. It was designated tentatively as Pi-g(t).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0032-0862.2004.00986.x
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  • 20
    Electronic Resource
    Electronic Resource
    Germline mutations in the ribonuclease L gene in families showing linkage with HPC1 (2002)
    [s.l.] : Nature Publishing Group
    Nature genetics 30 (2002), S. 181-184 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Although prostate cancer is the most common non-cutaneous malignancy diagnosed in men in the United States, little is known about inherited factors that influence its genetic predisposition. Here we report that germline mutations in the gene encoding ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng823
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