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  • Artikel: DFG Deutsche Nationallizenzen  (11)
  • 1995-1999  (5)
  • 1990-1994  (4)
  • 1980-1984  (2)
  • 1
    Digitale Medien
    Digitale Medien
    Synthesis and characterization of neutral MVO (M = technetium, rhenium) amine-thiol complexes containing a pendant phenylpiperidine group (1993)
    s.l. : American Chemical Society
    Inorganic chemistry 32 (1993), S. 3114-3124 
    Details
    ISSN: 1520-510X
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/ic00066a025
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  • 2
    Digitale Medien
    Digitale Medien
    A μ-Oxo-bis[iron(III) porphyrin] Complex (1995)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 51 (1995), S. 2252-2255 
    Details
    ISSN: 1600-5759
    Quelle: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Thema: Chemie und Pharmazie , Geologie und Paläontologie , Physik
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1107/S0108270195005701
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  • 3
    Digitale Medien
    Digitale Medien
    Novel iron meso-nitrooctaethylporphine complexes for the catalytic reaction of alkanes with molecular oxygen (1994)
    Springer
    Catalysis letters 24 (1994), S. 79-83 
    Details
    ISSN: 1572-879X
    Schlagwort(e): Metallonitroporphines ; oxidation ; isobutane ; propane
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Introducing nitro groups into themeso-positions of a metalloporphyrin converts a catalytically inactive complex into a highly active catalyst for the oxidation of alkanes with molecular oxygen. The degree of nitration correlates with both the Fe(III)/Fe(II) reduction potential and the catalytic activity.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00807377
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  • 4
    Digitale Medien
    Digitale Medien
    RFLP analysis of the MHC class III region defines unique haplotypes for the non-obese diabetic, cataract Shionogi and the non-obese non-diabetic mouse strains (1993)
    Springer
    Diabetologia 36 (1993), S. 727-733 
    Details
    ISSN: 1432-0428
    Schlagwort(e): MHC class III region ; non-obese diabetic mouse ; non-obese non-diabetic mouse ; cataract Shionogi mouse ; Type 1 (insulin-dependent) diabetes mellitus ; restriction fragment length polymorphisms
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The non-obese diabetic (NOD) mouse strain which spontaneously develops diabetes is a model for human Type 1 (insulin-dependent) diabetes mellitus. At least one of several genes controlling diabetes in the NOD mouse has been mapped to the MHC. Although previous experiments have implicated the MHC class II genes in the development of the disease, the existence of other MHC linked susceptibility genes has not been ruled out. In order to identify these susceptibility genes we have further characterized the MHC haplotype of the NOD mouse and two non-diabetic sister strains, the non-obese non-diabetic (NON) and cataract Shionogi (CTS). We have examined the mouse MHC class III region for the presence of homologous genes to 17 newly isolated human MHC class III region genes (G1, G2, G4, G6, G7a/valyl-tRNA synthetase, HSP70, G8, G9, G10, G12, G13, G14, G15, G16, G17 and G18). We detect unique hybridizing DNA fragments for 16 of the 17 genes in six inbred mouse strains (NOD, NON, CTS, B10, BALB/c and CBA/J) indicating that this part of the H-2 region is similar to the human MHC class III region. Using a panel of restriction enzymes we have defined RFLPs for 6 (G2, G6, HSP70, G12, G16, G18) of the 16 cross-hybridizing probes. The RFLPs demonstrate that NOD, NON and CTS mouse strains each have a distinct MHC haplotype in the MHC class III region.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00401143
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  • 5
    Digitale Medien
    Digitale Medien
    Allelic association between a Ser-9-Gly polymorphism in the dopamine D3 receptor gene and schizophrenia (1996)
    Springer
    Human genetics 〈Berlin〉 97 (1996), S. 714-719 
    Details
    ISSN: 1432-1203
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract We examined a Ser-9-Gly polymorphism in the dopamine D3 receptor gene for allelic association with schizophrenia in 133 patients currently treated with clozapine and 109 controls. Allele 1 (Ser-9) was significantly more frequent in the patients (69%) than in the controls (56%) (P = 0.004). The 1-1 genotype was more common (43% vs 30%) and the 2-2 genotype less common (5% vs 18%) in patients than in controls. When the patient group was subdivided on the basis of clinical response to clozapine, using a 20-point improvement in the global assessment scale as cut-off, genotype 1-1 was found to be more frequent among the non-responders (53% vs 36%, P = 0.04). To place our results in the context of previous studies of this polymorphism and schizophrenia, we performed a meta-analysis of all published data including the present sample. The combined analysis shows evidence for a modest association between genotype 1-1 and schizophrenia (odds ratio 1.25, 95% confidence interval 1.05– 1.49, P = 0.01). These results suggest that the Ser-9 allele, or a nearby polymorphism in linkage disequilibrium, results in a small increase in susceptibility to schizophrenia.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004390050125
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  • 6
    Digitale Medien
    Digitale Medien
    Allelic association between a Ser-9-Gly polymorphism in the dopamine D3 receptor gene and schizophrenia (1996)
    Springer
    Human genetics 〈Berlin〉 97 (1996), S. 714-719 
    Details
    ISSN: 1432-1203
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract We examined a Ser-9-Gly polymorphism in the dopamine D3 receptor gene for allelic association with schizophrenia in 133 patients currently treated with clozapine and 109 controls. Allele 1 (Ser-9) was significantly more frequent in the patients (69%) than in the controls (56%) (P = 0.004). The 1-1 genotype was more common (43% vs 30%) and the 2-2 genotype less common (5% vs 18%) in patients than in controls. When the patient group was subdivided on the basis of clinical response to clozapine, using a 20-point improvement in the global assessment scale as cut-off, genotype 1-1 was found to be more frequent among the non-responders (53% vs 36%,P = 0.04). To place our results in the context of previous studies of this polymorphism and schizophrenia, we performed a meta-analysis of all published data including the present sample. The combined analysis shows evidence for a modest association between genotype 1-1 and schizophrenia (odds ratio 1.25, 95% confidence interval 1.05–1:49,P = 0.01). These results suggest that the Ser-9 allele, or a nearby polymorphism in linkage disequilibrium, results in a small increase in susceptibility to schizophrenia.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02346178
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  • 7
    Digitale Medien
    Digitale Medien
    Effects of taxol and nocodazole on insulin secretion from isolated rat islets of Langerhans (1982)
    Springer
    Bioscience reports 2 (1982), S. 795-801 
    Details
    ISSN: 1573-4935
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract Taxol, a promotor of microtubule polymerization, and nocodazole, which induces microtubule depolymerization, used at concentrations known to be specific for these effects in other cell types, were each shown to inhibit glucose-stimulated insulin secretion from isolated rat islets of Langerhans. These findings suggest that the dynamic regulation of microtubule polymerization-depolymerization in pancreatic B ceils may be important for insulin secretion via the microtubule-microfilamentous system.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01114939
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  • 8
    Digitale Medien
    Digitale Medien
    Ovulation pattern in successive cycles in the baboon (1982)
    Springer
    Primates 23 (1982), S. 592-595 
    Details
    ISSN: 0032-8332
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The purpose of this study was to determine if the selection of the side on which ovulation occurs in successive cycles is a random event. Forty-seven baboons were observed for four consecutive cycles and 37 for two to three consecutive cycles. Side of ovulation was determined by laparoscopic examination. Of the 286 cycles studied, 146 cycles (51 %) showed ovulations on the left side and 140 cycles (49 %) on the right. Analysis of the data using two consecutive ovulations in 286 cycles revealed that the selection of the side of ovulation is a random event. However, when four consecutive ovulations observed in 47 baboons were analyzed, it was found that the observed pattern of ovulation was different from that expected from random chance (p〉0.05). There are 16 possible combinations in a sequence of four ovulations. Eight of 47 baboons (17 %) ovulated on the same side for four consecutive cycles, 15 baboons (32 %) ovulated three times on the same side for four ovulations, and 24 baboons (51 %) showed two ovulations on each side. Alternation of ovulation in a sequence of four consecutive ovulations was observed 48 times (25.5 %) and alternation of ovulation in two consecutive cycles was observed 106 times (51 %).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02373973
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  • 9
    Digitale Medien
    Digitale Medien
    Production of β-galactosidase from thermophilic fungus Rhizomucor sp (1997)
    Springer
    Journal of industrial microbiology and biotechnology 19 (1997), S. 239-245 
    Details
    ISSN: 1476-5535
    Schlagwort(e): Keywords: β-galactosidase; thermophilic fungus; Rhizomucor; extracellular; solid state fermentation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: A thermostable β-galactosidase was produced extracellularly by a thermophilic Rhizomucor sp, with maximum enzyme activity (0.21 U mg−1) after 4 days under submerged fermentation condition (SmF). Solid state fermentation (SSF) resulted in a nine-fold increase in enzyme activity (2.04 U mg−1). The temperature range for production of the enzyme was 38–55°C with maximum activity at 45°C. The optimum pH and temperature for the partially purified enzyme was 4.5 and 60°C, respectively. The enzyme retained its original activity on incubation at 60°C up to 1 h. Divalent cations like Co2+, Mn2+, Fe2+ and Zn2+ had strong inhibitory effects on the enzyme activity. The K m and V max for p-nitrophenyl-β- D-galactopyranoside and o-nitrophenyl-β - D-galactopyranoside were 0.39 mM, 0.785 mM and 232.1 mmol min−1 mg−1 respectively. The K m and V max for the natural substrate lactose were 66.66 μM and 0.20 μ mol min−1 mg−1.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/sj.jim.2900452
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  • 10
    Digitale Medien
    Digitale Medien
    Chitinolytic enzymes: their contribution to basic and applied research (1993)
    Springer
    World journal of microbiology and biotechnology 9 (1993), S. 468-475 
    Details
    ISSN: 1573-0972
    Schlagwort(e): Biocontrol agents ; chitinase/chitosanase ; chitinous waste ; single-cell protein ; ultrastructural studies
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Abstract After cellulose, chitin is the second most abundant renewable resource available in nature. Marine invertebrates and fungal biomass are the two main sources of chitinous waste, which is commercially exploited. The enzymes involved in chitin degradation have been particularly well studied. Such enzymes have applications in ultrastructural studies, in the preparation of chitooligosaccharides which show anti-tumour activity, as biocontrol agents and in single-cell protein production. Here, the contribution chitin enzymology can make to basic and applied research is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00328035
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