Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Articles: DFG German National Licenses  (17)
  • 1990-1994  (4)
  • 1985-1989  (13)
Source
  • Articles: DFG German National Licenses  (17)
Material
Years
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Ultrahigh vacuum sample mount for insulators (1986)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 57 (1986), S. 3134-3135 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: An ultrahigh vacuum sample mount for insulators which allows both good thermal conduction to the mount and accurate temperature measurement is described: good thermal connection between sample and mount is made with an indium layer. By melting an edge of the sample a thermocouple can be inserted directly into the crystal for accurate temperature measurement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1138956
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    S-Ibuprofen versus ibuprofen-racemate (1991)
    Springer
    Rheumatology international 11 (1991), S. 199-202 
    Details
    ISSN: 1437-160X
    Keywords: Ibuprofen ; Enantiomers ; Rheumatoid arthritis ; Prostaglandins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ibuprofen (ibu) is a racemic 2-arylpropionic acid non-steroidal anti-inflammatory drug whose activity is due mainly to the S-enantiomer. So far only the racemic compound is in clinical use. A double-blind randomized trial was carried out for a 2-week period in 50 patients with classical rheumatoid arthritis (RA) (Steinbrocker II–III) to compare the effectiveness and tolerance of S-ibu (400 mg T.I.D.) with that of the racemic compound (600 mg T.I.D.). Ritchie-index, limitation of movement, joint pain on pressure and pain at night decreased significantly in both groups. Due to lack of effectiveness, the dose had to be increased in 3 patients from the S-ibu group as well as in 6 patients from the racemic group resulting in mean daily doses of 1220 mg S-ibuprofen and 1870 mg racemic ibu. No statistically significant difference could be found between both groups concerning efficacy and unwanted effects. Therefore, S-ibu given alone may be advantageous because the metabolic load to the human body is reduced and patients are more likely to comply with drug doses of 1.2 g/day as compared to 1.8 g/day.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00332562
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Pharmacological differences between R(−)-and S(+)-ibuprofen (1989)
    Springer
    Inflammation research 27 (1989), S. 455-457 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Ibuprofen (IBU) is a non-steroidal anti-inflammatory drug exhibiting optical isomerism. Only the racemate is in clincal use. Inin vitro studies it has been demonstrated that only the S(+)-enantiomer inhibits the PG synthetase system. Nevertheless, it is widely believed that the sole use of the active isomer does not comprise any advantages since the inactive isomer is converted within the human body. In a triple cross-over study (300 mg S(+), 300 mg R(−), 600 mg racemic IBU;n=8), we could show that the converted R(−)-IBU after racemate administration provides for only one third of the AUC of S(+)-IBU obtained after S(+)-application. Highest S(+)-peak plasma levels were reached after S(+)-IBU, lower ones after racemate. We, therefore, studied 4 patients with classical rheumatoid arthritis treated with 2–3 doses of 500 mg of S(+)-IBU/day over a two week period. Significant clinical recovery (Ritchie-indexp〈0.01; analogue scale painp〈0.05, motionp〈0.01) was reached after one week. The results indicate that a reduction of dose and of metabolic load is possible if the S(+)-enantiomer is administrated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972851
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Hunter syndrome in Jews in Israel: further evidence for prenatal selection favoring the Hunter allele (1991)
    Springer
    Human genetics 〈Berlin〉 86 (1991), S. 531-533 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Among all the Jewish families with Hunter patients in Israel, 10 were Ashkenazi or Moroccan in origin. In those families, there was a paucity of new mutations. In addition, a significant deviation of the segregation ratio between the Hunter gene and the normal allele was demonstrated among the offspring of heterozygous mothers or siblings of affected children in these families. These results confirm and extend our previous observations suggesting selection in favor of the X chromosome carrying the Hunter allele among Ashkenazi and Moroccan Jews.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00194650
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Hunter syndrome among Ashkenazi Jews in Israel; evidence for prenatal selection favoring the Hunter allele (1985)
    Springer
    Human genetics 〈Berlin〉 71 (1985), S. 329-332 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Analysis of Ashkenazi families with Hunter patients in Israel demonstrated the complete absence of new mutations among the probands' mothers. Furthermore, in these families a significant deviation of the segregation ratio between the Hunter gene and the normal allele was demonstrated among offspring of heterozygous mothers or siblings of affected children. This may be due to pre- or postzygotic prenatal selection, favoring the X chromosome carrying the Hunter gene among Ashkenazi Jews.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00388459
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of S(+)- and R(−)-ibuprofen in volunteers and first clinical experience of S(+)-ibuprofen in rheumatoid arthritis (1990)
    Springer
    European journal of clinical pharmacology 38 (1990), S. 493-497 
    Details
    ISSN: 1432-1041
    Keywords: ibuprofen ; rheumatoid arthritis ; enantiomer ; stereoselectivity ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary S(+)-, R(−)- or racemic ibuprofen was administered orally to volunteers in doses of 150 mg, 300 mg and 500 mg pure S(+)-, 300 mg pure R(−)- and 600 mg racemic ibuprofen. The pharmacokinetic parameters in humans showed that S(+)-ibuprofen was not inverted to R(−)-ibuprofen, whereas R(−)-ibuprofen was inverted to S(+)-ibuprofen to a variable degree. S(+)-ibuprofen and R(−)-ibuprofen given alone more rapidly reached significantly higher maximal plasma concentrations than after the same doses of the racemic compound. The elimination half-lives and clearance values for all three forms of ibuprofen were comparable. The mean residence time of S(+)-ibuprofen after R(−)- and racemic ibuprofen was significantly longer than after administration of the pure S(+)-enantiomer. Judged by the AUC, the bioavailability of S(+)-ibuprofen was independent of the dose within the range tested. Administration of S(+)-ibuprofen to 6 rheumatic patients showed that the pharmacokinetic behaviour of S(+)-ibuprofen in patients was similar to that found in volunteers. S(+)-ibuprofen proved to be an effective analgesic antirheumatic drug in the dose range 1 to 1.5 g/day.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02336690
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Phospholipids accumulation in mucolipidosis IV cultured fibroblasts (1988)
    Springer
    Journal of inherited metabolic disease 11 (1988), S. 144-150 
    Details
    ISSN: 1573-2665
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cultured fibroblasts from mucolipidosis IV patients accumulated phospholipids when compared to normal controls or cells from other genotypes. The major stored compounds were identified as phosphatidylcholine, phosphatidylethanolamine and to a larger extent lysophosphatidylcholine and lysobisphosphatidic acid. Pulse chase experiments of32P-labelled phospholipids showed increased retention of these compounds in the mucolipidosis IV lines throughout the pulse and chase periods. Phospholipase A1, A2, C, D and lysophospholipase showed normal activity in the mucolipidosis IV lines and thus the metabolic cause for this storage remains to be identified.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01799863
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Untersuchungen zur Thermischen Umsetzung von Phenylcyclopentan, -hexan, -heptan und -octan in der Gasphase Teil der Dissertation A von Herrn Ho Són Lam, Akademie der Wissenschaften der DDR, Berlin-Leipzig 1983. (1985)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 327 (1985), S. 759-766 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Studies on Thermal Conversion of Phenyleyclopentane, -hexane, -heptane, and -octane in the Gas PhaseThe title compounds were pyrolyzed from 700 to 780°C in a metallic laboratory tubular reactor in the presence of steam. The reaction products were analyzed by gas chromatography and by a combination of gas chromatography and mass spectrometry. From the phenylcyclanes tested, more than 65 hydrocarbons could be detected in the liquids, besides gaseous reaction products. In most cases unambiguous structures could be derived by using different analytical methods.As typical initial-step products phenylcyclenes, ω-phenyl-1-alkenes and 1-phenyl-1-alkenes are formed by dehydrogenation and isomerization of the title compounds. The detection of phenylalkenes corresponds well with the isomerization of unsubstituted cyclanes to the corresponding α-olefines described in former papers.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19853270508
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Zur Pyrolyse unsubstituierter Cyclane - Produktbildungsselektivitäten, kinetische Parameter, mechanistische InterpretationenProfessor Dr.-Ing. Dr.h.c. Eberhard Leibnitz zum 75. Geburtstage gewidmet (1985)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 327 (1985), S. 10-20 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: On the Pyrolysis of Unsubstituted Cyclanes - Selectivity of the Formation of Reaction Products, Kinetic Parameters, Mechanistic InterpretationsThe thermal decompostion of cyclopentane (1), cyclohexane (2), cycloheptane (3), cyclooctane (4), cyclodecane (5), and cyclododecane (6) was studied in a laboratoryscale metallic tubular reactor at 650 to 850°C in the presence of steam. The kinetic parameters for the overall reactions were determined and the gaseous as well as the liquid reaction products were analyzed and identified by gas chromatography or by the coupling of gas chromatography and mass spectrometry, respectively. It could be shown that from all cyclanes the isomeric α-olefines are formed, if the conversion of the starting cyclanes is small. This supports the view that the cyclane → α-olefin isomerization is an important initial reaction in pyrolysis of 1 up to 6. The results also demonstrate that the main pathway of degradation is a radical chain mechanism via cyclanyl radicals with β(C—C) bond scission and 1.4 or 1.5-H-isomerization of alkenyl radicals as the most important reaction steps.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19853270104
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Non-self-similar blast waves (1991)
    Springer
    Combustion, explosion and shock waves 27 (1991), S. 342-351 
    Details
    ISSN: 1573-8345
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Conclusions Among the three non-self-similar methods studied in this paper, namely, the perturbation methods in η and y and the density-profile method, the latter method gives the best estimates of blast parameters in a wide range of shock-wave intensities. This work was performed with support from the Council on Natural Sciences and Technical Research.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00789669
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...